Prevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial

dc.creatorBahmanyar, ER
dc.creatorPaavonen, J
dc.creatorNaud, P
dc.creatorSalmeron, J
dc.creatorChow, SN
dc.creatorApter, D
dc.creatorKitchener, H
dc.creatorCastellsague, X
dc.creatorTeixeira, JC
dc.creatorSkinner, SR
dc.creatorJaisamrarn, U
dc.creatorLimson, GA
dc.creatorGarland, SM
dc.creatorSzarewski, A
dc.creatorRomanowski, B
dc.creatorAoki, F
dc.creatorSchwarz, TF
dc.creatorPoppe, WAJ
dc.creatorDe Carvalho, NS
dc.creatorHarper, DM
dc.creatorBosch, FX
dc.creatorRaillard, A
dc.creatorDescamps, D
dc.creatorStruyf, F
dc.creatorLehtinen, M
dc.creatorDubin, G
dc.date2012
dc.dateDEC
dc.date2014-07-30T18:08:07Z
dc.date2015-11-26T16:34:41Z
dc.date2014-07-30T18:08:07Z
dc.date2015-11-26T16:34:41Z
dc.date.accessioned2018-03-28T23:16:58Z
dc.date.available2018-03-28T23:16:58Z
dc.identifierGynecologic Oncology. Academic Press Inc Elsevier Science, v. 127, n. 3, n. 440, n. 450, 2012.
dc.identifier0090-8258
dc.identifierWOS:000311528500002
dc.identifier10.1016/j.ygyno.2012.08.033
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70204
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70204
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271273
dc.descriptionObjective. We evaluated baseline data from the PApilloma TRIal against Cancer In young Adults (PATRICIA; NCT00122681) on the association between behavioral risk factors and HPV infection and cervical abnormalities. Methods. Women completed behavioral questionnaires at baseline. Prevalence of HPV infection and cervical abnormalities (detected by cytological or histological procedures) and association with behavioral risk factors were analyzed by univariate and stepwise multivariable logistic regressions. Results. 16782 women completed questionnaires. Among 16748 women with data for HPV infection, 4059 (24.2%) were infected with any HPV type. Among 16757 women with data for cytological abnormalities, 1626 (9.7%) had a cytological abnormality, of whom 1170 (72.0%) were infected with at least one oncogenic HPV type including HPV-16 (22.7%) and HPV-18 (9.3%). Multivariable analysis (adjusted for age and region, N=14404) showed a significant association between infection with any HPV type and not living with a partner, smoking, age <15 years at first sexual intercourse, higher number of sexual partners during the past 12 months, longer duration of hormonal contraception and history of sexually transmitted infection (STI). For cervical abnormalities, only history of STI (excluding Chlamydia trachomatis) remained significant in the multivariable analysis after adjusting for HPV infection. Conclusions. Women reporting 3 + sexual partners in the past 12 months had the highest risk of HPV infection at baseline. HPV infection was the main risk factor for cervical abnormalities, and history of STIs excluding Chlamydia trachomatis increased risk to a lesser extent. Although behavioral factors can influence risk, all sexually active women are susceptible to HPV infection. (C) 2012 Elsevier Inc. All rights reserved.
dc.description127
dc.description3
dc.description440
dc.description450
dc.descriptionGlaxoSmithKline Biologicals SA
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationGynecologic Oncology
dc.relationGynecol. Oncol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectHuman papillomavirus
dc.subjectRisk factor
dc.subjectPrevalence
dc.subjectBehavior
dc.subjectQuestionnaire
dc.subjectHuman-papillomavirus Infection
dc.subjectGenital Human-papillomavirus
dc.subjectSquamous Intraepithelial Lesions
dc.subjectChlamydia-trachomatis Infection
dc.subjectSexual-behavior
dc.subjectCollaborative Reanalysis
dc.subjectIndividual Data
dc.subjectPooled Analysis
dc.subjectHormonal Contraceptives
dc.subjectTobacco Smoking
dc.titlePrevalence and risk factors for cervical HPV infection and abnormalities in young adult women at enrolment in the multinational PATRICIA trial
dc.typeArtículos de revistas


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