Analysis of angiogenic factors and cyclooxygenase-2 expression in cartilaginous tumors - clinical and histological correlation

dc.creatorCintra, FF
dc.creatorEtchebehere, M
dc.creatorGoncalves, JCB
dc.creatorCassone, AE
dc.creatorAmstalden, EMI
dc.date2011
dc.date2014-07-30T13:48:54Z
dc.date2015-11-26T16:34:39Z
dc.date2014-07-30T13:48:54Z
dc.date2015-11-26T16:34:39Z
dc.date.accessioned2018-03-28T23:16:55Z
dc.date.available2018-03-28T23:16:55Z
dc.identifierClinics. Hospital Clinicas, Univ Sao Paulo, v. 66, n. 9, n. 1591, n. 1596, 2011.
dc.identifier1807-5932
dc.identifierWOS:000297498400015
dc.identifier10.1590/S1807-59322011000900015
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54541
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54541
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271259
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionOBJECTIVES: To study the role of angiogenesis and cyclooxygenase-2 expression in cartilaginous tumors and correlate these factors with prognosis. INTRODUCTION: For chondrosarcoma, the histological grade is the current standard for predicting tumor outcome. However, a low-grade chondrosarcoma can follow an aggressive course-as monitored by sequential imaging techniques-even when it is histologically indistinguishable from an enchondroma. Therefore, additional tools are needed to help identify the biological potential of these tumors. The degree of angiogenesis that is induced by the tumor could assist in this task. Angiogenesis can be quantified by measuring the expression of vascular endothelial growth factor and CD34, and cyclooxygenase-2 can induce angiogenesis by stimulating the production of proangiogenic factors. METHODS: In total, 21 enchondromas and 58 conventional chondrosarcomas were studied by examining the clinical and histopathological findings in conjunction with the immunostaining markers of angiogenesis and cyclooxygenase-2 expression. RESULTS: The significant variables that were associated with poor outcome were 1) higher-grade chondrosarcomas, 2) tumors that developed in flat bones, and 3) over-expression of CD34 (with a median count that was higher than 5.9 vessels in 5 high power fields). Moreover, CD34 expression (measured using the Chalkley method) revealed significantly higher microvessel density in flat bone chondrosarcomas. DISCUSSION: Previous studies have shown a positive correlation between Chalkley microvessel density and histological grade; however, in our sample, we found that the former is predictive of the outcome. Chondrosarcomas in flat bones have been shown to correlate with a poor prognosis. We also found that CD34 microvessel density values were significantly higher in flat-bone chondrosarcomas. This could explain-at least in part-the more aggressive biological course that is taken by these tumors. CONCLUSIONS: These results provide evidence that CD34 microvessel density in chondrosarcomas can be helpful in predicting patient outcome and may add to our understanding of chondrosarcoma pathogenesis.
dc.description66
dc.description9
dc.description1591
dc.description1596
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [09/51473-0]
dc.languageen
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationClinics
dc.relationClinics
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectHistological grades
dc.subjectFlat bones
dc.subjectCD34
dc.subjectVEGF
dc.subjectPrognosis
dc.subjectEndothelial Growth-factor
dc.subjectChondrosarcoma
dc.subjectBone
dc.subjectOsteosarcoma
dc.subjectVegf
dc.subjectOverexpression
dc.subjectDiagnosis
dc.subjectPrognosis
dc.subjectDensity
dc.subjectCancer
dc.titleAnalysis of angiogenic factors and cyclooxygenase-2 expression in cartilaginous tumors - clinical and histological correlation
dc.typeArtículos de revistas


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