Paucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential

dc.creatorLopes, SCP
dc.creatorAlbrecht, L
dc.creatorCarvalho, BO
dc.creatorSiqueira, AM
dc.creatorThomson-Luque, R
dc.creatorNogueira, PA
dc.creatorFernandez-Becerra, C
dc.creatordel Portillo, HA
dc.creatorRussell, BM
dc.creatorRenia, L
dc.creatorLacerda, MVG
dc.creatorCosta, FTM
dc.date2014
dc.dateMAY 1
dc.date2014-07-30T14:30:55Z
dc.date2015-11-26T16:34:28Z
dc.date2014-07-30T14:30:55Z
dc.date2015-11-26T16:34:28Z
dc.date.accessioned2018-03-28T23:16:41Z
dc.date.available2018-03-28T23:16:41Z
dc.identifierJournal Of Infectious Diseases. Oxford Univ Press Inc, v. 209, n. 9, n. 1403, n. 1407, 2014.
dc.identifier0022-1899
dc.identifier1537-6613
dc.identifierWOS:000334689700012
dc.identifier10.1093/infdis/jiu018
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59172
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59172
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271204
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThere is now a growing body of evidence that challenges the current view that Plasmodium vivax-infected erythrocyte (Pv-iE) are unable to sequester. Here we used ex vivo adhesion assays with Pv-iE before and after maturation to demonstrate a higher binding potential of schizonts compared to other asexual stages. These experimental results are correlated with our observations in a panel of 50 vivax malaria patients where schizonts were completely absent in 27 isolates, and few schizonts were observed in the remaining patients. These observations prompt a paradigm shift in P. vivax biology and open avenues to investigate the role of Pv-iE sequestration.
dc.description209
dc.description9
dc.description1403
dc.description1407
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniversal [470688/2012-2, 471066/2012-5]
dc.descriptionDoencas Negligenciadas [404154/2012-3]
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2012/16525-2]
dc.descriptionUniversal [470688/2012-2, 471066/2012-5]
dc.descriptionDoencas Negligenciadas [404154/2012-3]
dc.languageen
dc.publisherOxford Univ Press Inc
dc.publisherCary
dc.publisherEUA
dc.relationJournal Of Infectious Diseases
dc.relationJ. Infect. Dis.
dc.rightsfechado
dc.rightshttp://www.oxfordjournals.org/access_purchase/self-archiving_policyb.html
dc.sourceWeb of Science
dc.subjectmalaria
dc.subjectPlasmodium vivax
dc.subjectschizonts
dc.subjectdisproportionality
dc.subjectcytoadhesion
dc.subjectsequestration
dc.subjectMalaria
dc.titlePaucity of Plasmodium vivax Mature Schizonts in Peripheral Blood Is Associated With Their Increased Cytoadhesive Potential
dc.typeArtículos de revistas


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