An Overview of the Role of Molecular Chaperones in Protein Homeostasis

dc.creatorTiroli-Cepeda, AO
dc.creatorRamos, CHI
dc.date2011
dc.dateFEB
dc.date2014-07-30T13:48:48Z
dc.date2015-11-26T16:34:16Z
dc.date2014-07-30T13:48:48Z
dc.date2015-11-26T16:34:16Z
dc.date.accessioned2018-03-28T23:16:29Z
dc.date.available2018-03-28T23:16:29Z
dc.identifierProtein And Peptide Letters. Bentham Science Publ Ltd, v. 18, n. 2, n. 101, n. 109, 2011.
dc.identifier0929-8665
dc.identifierWOS:000287308000002
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54493
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54493
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271151
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCells require a protein quality control (PQC) system to obtain a correct balance between folding and the degradation of incorrectly folded or misfolded proteins. This system maintains protein homeostasis and is essential for life. Key components of the PQC are molecular chaperones, which compose a ubiquitous class of proteins that mediate protein quality control by aiding in both the correct folding of proteins and the elimination of proteins that are misfolded due to cellular stress or mutation. Recent studies showed that protein homeostasis has an important role in nutrition and aging, increasing the relevance of the heat shock response to human health. This review summarizes our current knowledge of the molecular chaperone system and its role in protein homeostasis.
dc.description18
dc.description2
dc.description101
dc.description109
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherBentham Science Publ Ltd
dc.publisherSharjah
dc.publisherEmirados Árabes Unidos
dc.relationProtein And Peptide Letters
dc.relationProtein Pept. Lett.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectHeat shock protein
dc.subjectmolecular chaperones
dc.subjectprotein homeostasis
dc.subjectprotein quality control
dc.subjectprotein folding
dc.subjectHeat-shock Proteins
dc.subjectHuman-disease
dc.subjectAmyloid Fibrils
dc.subjectHsp90
dc.subjectHsp40
dc.subjectHsp70
dc.subjectAggregation
dc.subjectSugarcane
dc.subjectDomain
dc.subjectMechanism
dc.titleAn Overview of the Role of Molecular Chaperones in Protein Homeostasis
dc.typeArtículos de revistas


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