ACUTE HEPATOTOXICITY OF Crotalus durissus terrificus (SOUTH AMERICAN RATTLESNAKE) VENOM IN RATS

dc.creatorFranca, RF
dc.creatorVieira, RP
dc.creatorFerrari, EF
dc.creatorSouza, RA
dc.creatorOsorio, RAL
dc.creatorPrianti-Jr, ACG
dc.creatorHyslop, S
dc.creatorZamuner, SR
dc.creatorCogo, JC
dc.creatorRibeiro, W
dc.date2009
dc.date2014-07-30T13:43:36Z
dc.date2015-11-26T16:33:49Z
dc.date2014-07-30T13:43:36Z
dc.date2015-11-26T16:33:49Z
dc.date.accessioned2018-03-28T23:15:52Z
dc.date.available2018-03-28T23:15:52Z
dc.identifierJournal Of Venomous Animals And Toxins Including Tropical Diseases. Cevap-unesp, v. 15, n. 1, n. 61, n. 78, 2009.
dc.identifier1678-9199
dc.identifierWOS:000264366500007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54206
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54206
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1271000
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionVenom of the South American rattlesnake, Crotalus durissus terrificus (Cdt), presents myotoxic and neurotoxic outcomes, but reports on its effects on the liver are scarce. This study examined the hepatotoxicity resulting from Cdt venom administration (100, 200 and 300 mu g/kg) in male Wistar rats. Animals were studies at 3, 6, 9 and 12 hours after venom injection. The hepatotoxicity was assessed through serum levels of aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), gamma glutamyl transferase (GGT), bilirrubin and also by histopathological evaluation. All the different concentrations of Cdt venom resulted in increased levels of hepatic enzymes, when compared with the control group, except for the 100 mu g/kg dose, which presented normal levels at 9 and 12 hours after venom administration. Bilirrubin levels remained unchanged by Cdt venom. Histological analysis revealed endothelial damage, inflammatory cell infiltration, as well as sinusoidal and portal congestion. Based on these observations, we may conclude that Cdt venom causes dose- and time-dependent hepatic damage in rats, characterized by elevated hepatic enzyme levels and histological alterations.
dc.description15
dc.description1
dc.description61
dc.description78
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFVE/UNIVAP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherCevap-unesp
dc.publisherBotucatu
dc.publisherBrasil
dc.relationJournal Of Venomous Animals And Toxins Including Tropical Diseases
dc.relationJ. Venom. Anim. Toxins Trop. Dis.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectCrotalus durissus terrificus
dc.subjecthepatotoxicity
dc.subjecthistology
dc.subjectAST
dc.subjectALT
dc.subjectrattlesnake
dc.subjectliver enzymes
dc.subjectvenom
dc.subjectThrombin-like Enzyme
dc.subjectPhospholipase A(2)
dc.subjectSnake-venom
dc.subjectBiological-activities
dc.subjectPlatelet Activation
dc.subjectMacrophage Function
dc.subjectCascavella Venom
dc.subjectCrotoxin
dc.subjectConvulxin
dc.subjectEnvenomation
dc.titleACUTE HEPATOTOXICITY OF Crotalus durissus terrificus (SOUTH AMERICAN RATTLESNAKE) VENOM IN RATS
dc.typeArtículos de revistas


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