Study of candidate genes for dyslexia in Brazilian individuals

dc.creatorSvidnicki, MCCM
dc.creatorSalgado, CA
dc.creatorLima, RF
dc.creatorCiasca, SM
dc.creatorSecolin, R
dc.creatorPomilio, MCA
dc.creatorJunqueira, PA
dc.creatorPinto, MS
dc.creatorPereira, MM
dc.creatorSartorato, EL
dc.date2013
dc.date2014-07-31T14:18:43Z
dc.date2015-11-26T16:33:47Z
dc.date2014-07-31T14:18:43Z
dc.date2015-11-26T16:33:47Z
dc.date.accessioned2018-03-28T23:15:49Z
dc.date.available2018-03-28T23:15:49Z
dc.identifierGenetics And Molecular Research. Funpec-editora, v. 12, n. 4, n. 5356, n. 5364, 2013.
dc.identifier1676-5680
dc.identifierWOS:000331608000124
dc.identifier10.4238/2013.November.7.10
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75258
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75258
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270987
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionDyslexia or reading disability (RD) is the most common childhood learning disorder and a significantly heritable trait. Many recent studies have investigated the genetic basis of dyslexia, and several candidate genes have been proposed. Among these, DCDC2 and KIAA0319 have emerged as the strongest candidate genes for dyslexia; however studies have not provided uniformly supportive results. The aim of this study was to assess the contribution of proposed candidate genes to the molecular etiology of dyslexia in a Brazilian sample. Large deletions and duplications in the candidate genes DCDC2, KIAA0319, and ROBO1 were investigated in 51 dyslexic subjects. Furthermore, a family-based association study was performed to investigate whether associations observed in other populations with variants in the DCDC2 and KIAA0319 genes were reproducible in Brazilian dyslexic individuals. Our analysis did not detect any deletions or duplications in the genes studied, and we found no evidence that the allelic variants in the two candidate genes were significantly associated with RD in our sample. Our data do not support a role of the DCDC2/KIAA0319 locus in influencing dyslexia as a categorical trait. Given the genetic complexity of dyslexia, it is plausible that both genes contribute to an increased risk, but the relative influence of these 2 genes on RD varies in different study samples, and/or depends on analytical approaches.
dc.description12
dc.description4
dc.description5356
dc.description5364
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionDresser-Rand Guascor Company
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherFunpec-editora
dc.publisherRibeirao Preto
dc.publisherBrasil
dc.relationGenetics And Molecular Research
dc.relationGenet. Mol. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectDyslexia
dc.subjectReading disability
dc.subjectCandidate genes
dc.subjectDCDC2
dc.subjectKIAA0319
dc.subjectDevelopmental Dyslexia
dc.subjectReading Disabilities
dc.subjectSusceptibility Gene
dc.subjectNeuronal Migration
dc.subjectChromosome 6p
dc.subjectKiaa0319
dc.subjectAssociation
dc.subjectFamilies
dc.subjectDcdc2
dc.subjectIdentification
dc.titleStudy of candidate genes for dyslexia in Brazilian individuals
dc.typeArtículos de revistas


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