Automated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F-2 mice

dc.creatorValentinuzzi, VS
dc.creatorKolker, DE
dc.creatorVitaterna, MH
dc.creatorShimomura, K
dc.creatorWhiteley, A
dc.creatorLow-Zeddies, S
dc.creatorTurek, FW
dc.creatorFerrari, EAM
dc.creatorPaylor, R
dc.creatorTakahashi, JS
dc.date1998
dc.dateSEP-OCT
dc.date2014-12-02T16:26:57Z
dc.date2015-11-26T16:33:34Z
dc.date2014-12-02T16:26:57Z
dc.date2015-11-26T16:33:34Z
dc.date.accessioned2018-03-28T23:15:29Z
dc.date.available2018-03-28T23:15:29Z
dc.identifierLearning & Memory. Cold Spring Harbor Lab Press, v. 5, n. 41763, n. 391, n. 403, 1998.
dc.identifier1072-0502
dc.identifierWOS:000076812700012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55208
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55208
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55208
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270900
dc.descriptionThe most commonly measured mouse behavior in fear conditioning tests is freezing. A technical Limitation, particularly for genetic studies, is the method of direct observation used for quantifying this response, with the potential for bias or inconsistencies. We report the use of a computerized method based on latency between photobeam interruption measures as a reliable scoring criterion in mice. The different computer measures obtained during contextual fear conditioning tests showed high correlations with hand-scored freezing; r values ranged from 0.87 to 0.94. Previously reported strain differences between C57BL/6J and DBA/2J in context-dependent fear conditioning were also detected by the computer-based system. In addition, the use of computer-scored freezing of 199 (BALB/cJ x C57BL/6J)F-2 mice enabled us to detect a suggestive gender-dependent chromosomal locus for contextual fear conditioning on distal chromosome 8 by QTL analysis. Automation of freeze scoring would significantly increase efficiency and reliability of this learning and memory test.
dc.descriptiono TEXTO COMPLETO DESTE ARTIGO, ESTARÁ DISPONÍVEL À PARTIR DE AGOSTO DE 2015.
dc.description5
dc.description41763
dc.description391
dc.description403
dc.languageen
dc.publisherCold Spring Harbor Lab Press
dc.publisherPlainview
dc.publisherEUA
dc.relationLearning & Memory
dc.relationLearn. Mem.
dc.rightsembargo
dc.sourceWeb of Science
dc.subjectInbred Strains
dc.subjectLength Polymorphisms
dc.subjectMendelian Factors
dc.subjectMutant Mice
dc.subjectLinkage Map
dc.subjectGenetic-map
dc.subjectMemory
dc.subjectEmotion
dc.titleAutomated measurement of mouse freezing behavior and its use for quantitative trait locus analysis of contextual fear conditioning in (BALB/cJ x C57BL/6J)F-2 mice
dc.typeArtículos de revistas


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