Infliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet

dc.creatorBarbuio, R
dc.creatorMilanski, M
dc.creatorBertolo, MB
dc.creatorSaad, MJ
dc.creatorVelloso, LA
dc.date2007
dc.dateSEP
dc.date2014-07-30T14:33:28Z
dc.date2015-11-26T16:33:22Z
dc.date2014-07-30T14:33:28Z
dc.date2015-11-26T16:33:22Z
dc.date.accessioned2018-03-28T23:15:13Z
dc.date.available2018-03-28T23:15:13Z
dc.identifierJournal Of Endocrinology. Soc Endocrinology, v. 194, n. 3, n. 539, n. 550, 2007.
dc.identifier0022-0795
dc.identifierWOS:000249611100008
dc.identifier10.1677/JOE-07-0234
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60173
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60173
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270832
dc.descriptionNon-alcoholic fatty liver disease, induced by nutritional factors, is one of the leading causes of hepatic dysfunction in the modern world. The activation of proinflammatory signaling in the liver, which is induced by systemic and locally produced cytokines, and the development of hepatic insulin resistance are two important factors associated with the progression from steatosis to steatohepatitis, a pre-cirrhotic condition. The objective of the present study was to evaluate the effect of inhibition of tumour necrosis factor (TNF)-alpha, using the monoclonal antibody infliximab, on the expression of cytokines, induction of steatosis and fibrosis, and insulin signal transduction in the liver of Wistar rats fed a high-fat diet. Ten days of treatment with infliximab significantly reduced the expression of the proinflammatory markets, TNF-alpha, IL-6, IL-1 beta, and SOCS-3, in the liver of rats fed a high-fat diet. This was accompanied by reduced fat deposition and fibrosis and by improved insulin signal transduction through insulin receptor (IR)/IR substrate/Akt/FOXO1 and JAK2/STAT3 pathways. In conclusion, short-term inhibition of TNF-alpha. with infliximab reduces inflammation and steatosis/fibrosis, while improving insulin signal transduction in an animal model treated with a high-fat diet.
dc.description194
dc.description3
dc.description539
dc.description550
dc.languageen
dc.publisherSoc Endocrinology
dc.publisherBristol
dc.publisherInglaterra
dc.relationJournal Of Endocrinology
dc.relationJ. Endocrinol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectNecrosis-factor-alpha
dc.subjectInflammatory-bowel-disease
dc.subjectInduced Diabetes-mellitus
dc.subjectNonalcoholic Steatohepatitis
dc.subjectHepatic Steatosis
dc.subjectObese-patients
dc.subjectTyrosine Phosphorylation
dc.subjectReceptor Antagonist
dc.subjectMetabolic Syndrome
dc.subjectAngiotensin-ii
dc.titleInfliximab reverses steatosis and improves insulin signal transduction in liver of rats fed a high-fat diet
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución