Comprehensive analysis of Ginkgo tablets by easy ambient sonic spray ionization mass spectrometry

dc.creatorBorges, EM
dc.creatorVolmer, DA
dc.creatorEberlin, MN
dc.date2013
dc.dateAUG
dc.date2014-07-30T14:00:26Z
dc.date2015-11-26T16:33:21Z
dc.date2014-07-30T14:00:26Z
dc.date2015-11-26T16:33:21Z
dc.date.accessioned2018-03-28T23:15:11Z
dc.date.available2018-03-28T23:15:11Z
dc.identifierCanadian Journal Of Chemistry-revue Canadienne De Chimie. Canadian Science Publishing, Nrc Research Press, v. 91, n. 8, n. 671, n. 678, 2013.
dc.identifier0008-4042
dc.identifierWOS:000324303700004
dc.identifier10.1139/cjc-2013-0037
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56393
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56393
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270825
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionWe report here that easy ambient sonic spray ionization - mass spectrometry (EASI-MS) allowed direct, rapid, and comprehensive analysis of active components (e. g., terpenetrilactones and intact flavonol glycosides) in Ginkgo tablets. Unlike conventional methods that hydrolyze flavonol glycosides to flavonoids prior to analysis, EASI-MS detects intact flavonol glycosides directly from the tablets enabling differentiation of these natural glycosides from the synthetic flavonoids. Adulteration of Ginkgo tablets is therefore readily recognized in less than 10 s measurement time. Sample preparation is simple and requires only 0.5 mL of methanol and a mortar and pestle. Additionally, no reference standards are needed and a comparison is made to a certified Ginkgo tablet. To demonstrate these abilities, 22 commercial Ginkgo tablets were analyzed by EASI-MS. The data revealed large variations of ingredients and strong deviations from the specified Ginkgo extract levels. These results emphasize the importance of monitoring Ginkgo products using appropriate methodologies as suggested in our work. The technique may replace more demanding LC-MS/MS methods, which can achieve comparable results but are considerably more labor-intensive. Importantly, the presented method is cheaper, faster, and much simpler to operate than chromatography-based mass spectrometric techniques.
dc.description91
dc.description8
dc.description671
dc.description678
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionAlfried Krupp von Bohlen und Halbach-Stiftung
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [11/07466-0]
dc.languageen
dc.publisherCanadian Science Publishing, Nrc Research Press
dc.publisherOttawa
dc.publisherCanadá
dc.relationCanadian Journal Of Chemistry-revue Canadienne De Chimie
dc.relationCan. J. Chem.-Rev. Can. Chim.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecteasy ambient sonic spray ionization - mass spectrometry (EASI-MS)
dc.subjectflavonol glycosides
dc.subjectGinkgo biloba
dc.subjectterpenetrilactones
dc.subjectGinkgo tablet adulteration
dc.subjectBiloba Leaves
dc.subjectFingerprint Analysis
dc.subjectProducts
dc.subjectSupplements
dc.subjectComponents
dc.subjectLactones
dc.titleComprehensive analysis of Ginkgo tablets by easy ambient sonic spray ionization mass spectrometry
dc.typeArtículos de revistas


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