The effect of lead on the eruption rates of incisor teeth in rats

dc.creatorGerlach, RF
dc.creatorToledo, DB
dc.creatorNovaes, PD
dc.creatorMerzel, J
dc.creatorLine, SRP
dc.date2000
dc.dateNOV
dc.date2014-12-02T16:26:51Z
dc.date2015-11-26T16:33:13Z
dc.date2014-12-02T16:26:51Z
dc.date2015-11-26T16:33:13Z
dc.date.accessioned2018-03-28T23:14:59Z
dc.date.available2018-03-28T23:14:59Z
dc.identifierArchives Of Oral Biology. Pergamon-elsevier Science Ltd, v. 45, n. 11, n. 951, n. 955, 2000.
dc.identifier0003-9969
dc.identifierWOS:000089560100005
dc.identifier10.1016/S0003-9969(00)00072-8
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/75096
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/75096
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/75096
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270774
dc.descriptionThe effects of lead on the continuously erupting rat incisors under normo-, hyper- and hypofunctional conditions were investigated. Left lower incisors of 20 rats were rendered unimpeded (hypofunctional) by cutting them out of occlusion every 2 days; the right lower incisors of these rats were considered hyperfunctional. Measurements on normally growing teeth (normofunctional) were carried out in a group of ten rats whose teeth were not cut but only marked every 2 days. On day 7 of the experiment, half of the rats from these two groups were given a single intraperitoneal injection of lead acetate (40 mg/kg), and the other half received sodium acetate (22 mg/kg). Another group of 15 rats was used to obtain blood samples for lead determination 1 h, and 10, 20, and 30 days after lead administration. Animals were killed on day 32. Hypofunctional incisors from lead-treated rats erupted more slowly than control ones (P < 0.05). These results show a previously unreported toxic effect of heavy metals. (C) 2000 Elsevier Science Ltd. All rights reserved.
dc.description45
dc.description11
dc.description951
dc.description955
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationArchives Of Oral Biology
dc.relationArch. Oral Biol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjecteruption
dc.subjectlead
dc.subjectmetals
dc.subjectincisor
dc.subjectrat
dc.subjectMetal-binding-site
dc.subjectPeriodontal-ligament
dc.subjectTooth Eruption
dc.subjectExtracellular-matrix
dc.subjectCollagen
dc.subjectMetabolism
dc.subjectTurnover
dc.subjectTissues
dc.subjectForces
dc.subjectCells
dc.titleThe effect of lead on the eruption rates of incisor teeth in rats
dc.typeArtículos de revistas


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