Effects of Lercanidipine on Bone Density and Bone Repair in Spontaneously Hypertensive Rats

dc.creatorBastos, MF
dc.creatorde Araujo, IV
dc.creatorBrilhante, FV
dc.creatorPires, AG
dc.creatorGoncalves, TED
dc.creatorNapimoga, MH
dc.creatorMarques, MR
dc.creatorDuarte, PM
dc.date2013
dc.dateFEB
dc.date2014-07-30T17:21:34Z
dc.date2015-11-26T16:33:12Z
dc.date2014-07-30T17:21:34Z
dc.date2015-11-26T16:33:12Z
dc.date.accessioned2018-03-28T23:14:58Z
dc.date.available2018-03-28T23:14:58Z
dc.identifierImplant Dentistry. Lippincott Williams & Wilkins, v. 22, n. 1, n. 49, n. 54, 2013.
dc.identifier1056-6163
dc.identifierWOS:000313728500009
dc.identifier10.1097/ID.0b013e3182777650
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/64992
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/64992
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270771
dc.descriptionPurpose: To evaluate the effects of the lercanidipine on bone healing (BH) and bone density (BD) in the tibiae of spontaneously hypertensive rats (SHR), using histometric and tartrate-resistant acid phosphatase (TRAP) expression analyses. Materials and Methods: Wistar and SHR were assigned to one of the following groups: normotensive rats (NTR) (n = 15), untreated SHR (n = 15), and lercanidipine-treated SHR (n = 15). The latter group was treated daily with lercanidipine for 6 weeks. Two weeks after the beginning of drug administration, a critical-sized surgical defect was created in the right tibia of all groups, whereas the contralateral tibia remained without defect. The animals were killed 30 days after the creation of the bone defect. Results: There were no significant differences among the groups for BH, trabecular BD, and the number of TRAP+ cells in the newly formed cortical bone (P > 0.05). SHR presented significantly lower cortical BD and increased cortical levels of TRAP+ cells, when compared with NTR and lercanidipine-treated SHR (P < 0.05). Conclusion: SHR presented a lower cortical BD and increased levels of TRAP+ cells. In addition, the treatment of SHR with lercanidipine during 6 weeks was able to revert the deleterious effects of hypertension on cortical BD and on the number of TRAP+ cells in the tibia of SHR. (Implant Dent 2013;22:49-54)
dc.description22
dc.description1
dc.description49
dc.description54
dc.languageen
dc.publisherLippincott Williams & Wilkins
dc.publisherPhiladelphia
dc.publisherEUA
dc.relationImplant Dentistry
dc.relationImplant Dent.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectlercanidipine
dc.subjecthypertension
dc.subjectbone density
dc.subjectspontaneously hypertensive rats
dc.subjectTRAP protein
dc.subjectOsteoblastic Cells
dc.subjectAngiotensin-ii
dc.subjectCalcium-antagonist
dc.subjectAmlodipine
dc.subjectDifferentiation
dc.subjectOsteoporosis
dc.subjectBenidipine
dc.subjectMetabolism
dc.subjectResorption
dc.subjectDefects
dc.titleEffects of Lercanidipine on Bone Density and Bone Repair in Spontaneously Hypertensive Rats
dc.typeArtículos de revistas


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