Association of TGF-beta(1), CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents

dc.creatorde Faria, ICJ
dc.creatorde Faria, EJ
dc.creatorToro, AADC
dc.creatorRibeiro, JD
dc.creatorBertuzzo, CS
dc.date2008
dc.dateMAY-JUN
dc.date2014-07-30T13:51:16Z
dc.date2015-11-26T16:33:06Z
dc.date2014-07-30T13:51:16Z
dc.date2015-11-26T16:33:06Z
dc.date.accessioned2018-03-28T23:14:48Z
dc.date.available2018-03-28T23:14:48Z
dc.identifierJornal De Pediatria. Soc Brasil Pediatria, v. 84, n. 3, n. 203, n. 210, 2008.
dc.identifier0021-7557
dc.identifierWOS:000257402800004
dc.identifier10.2223/JPED.1783
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55078
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55078
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270731
dc.descriptionObjective: To verify the association of transforming growth factor-beta(1)(TGF-beta(1)) (C-509T and T869C), CD14 (C-159T), IL-4 (C-590T), IL-4R (ILe50Val) and ADAM33 (S_2) gene polymorphisms with asthma severity in a sample of patients with mild, moderate and severe persistent atopic asthma. Methods: A clinical, laboratory, prospective study was performed in patients with persistent atopic asthma, compared to a control group at Hospital Universitario da Universidade Estadual de Campinas between 2006 and 2007. Analysis of the TGF-beta(1) T869C gene polymorphism was performed using the technique polymerase chain reaction (PCR) + amplification refractory mutation system (ARMS). TGF-beta(1) C-509T, CD14 C-159T, IL-4 C-590T, IL-4Ra ILe50Val, and ADAM33 S2 gene polymorphisms were detected by PCR and restriction enzyme. Results: This study included 88 patients with persistent atopic asthma (27 mild, 23 moderate and 38 severe) and 202 healthy blood donors. As to T869C polymorphism (TGF-beta(1)), there was an association between the CC genotype and patients with severe asthma. There was no association in polymorphisms C-509T (TGF-beta(1)), C-590T (IL-4) and S_2 (ADAM33). When distribution of C-159T polymorphism genotype frequency (CD14) in severe asthma was compared with the control group, there was a significant result with the TT genotype. There was significant association of the Val/Val genotype (IL-4R) with mild asthma. Conclusion: Our results indicate that T869C (TGF-beta(1)), C-159T (CD14) and Val/Val (IL-4R) polymorphisms might be involved in modulation of asthma severity.
dc.description84
dc.description3
dc.description203
dc.description210
dc.languageen
dc.publisherSoc Brasil Pediatria
dc.publisherRio De Janeiro, Rj
dc.publisherBrasil
dc.relationJornal De Pediatria
dc.relationJ. Pediatr.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectasthma genes
dc.subjectpolymorphisms
dc.subjectSNP
dc.subjectADAM33
dc.subjectCD14
dc.subjectTGF-beta(1)
dc.subjectSingle-nucleotide Polymorphisms
dc.subjectSerum Immunoglobulin-e
dc.subjectLung-function Decline
dc.subjectReceptor-alpha Gene
dc.subjectGrowth-factor-beta
dc.subjectTransforming Growth-factor-beta-1
dc.subjectPromoter Polymorphism
dc.subjectAtopic Asthma
dc.subjectChildhood Asthma
dc.subjectBronchial-asthma
dc.titleAssociation of TGF-beta(1), CD14, IL-4, IL-4R and ADAM33 gene polymorphisms with asthma severity in children and adolescents
dc.typeArtículos de revistas


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