Accelerated recovery of glycerol-induced acute renal failure in rats with previous partial hepatectomy

dc.creatorHomsi, E
dc.creatorDias, EPD
dc.creatorFigueiredo, JF
dc.creatorGontijo, JA
dc.date1998
dc.dateNOV-DEC
dc.date2014-07-30T13:43:20Z
dc.date2015-11-26T16:33:03Z
dc.date2014-07-30T13:43:20Z
dc.date2015-11-26T16:33:03Z
dc.date.accessioned2018-03-28T23:14:43Z
dc.date.available2018-03-28T23:14:43Z
dc.identifierExperimental Nephrology. Karger, v. 6, n. 6, n. 551, n. 556, 1998.
dc.identifier1018-7782
dc.identifierWOS:000076950800012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54049
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54049
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270710
dc.descriptionSeveral studies have reported a favorable effect following the administration of growth factors during the course of acute renal failure. To evaluate the effect of an increased endogenous production of growth factors, rats underwent 70% hepatectomy before glycerol-induced acute renal failure. The renal function was then monitored 12 and 48 h after glycerol injection in conscious rats. Twelve hours after the induction of acute renal failure, a reduction in creatinine clearance and sodium reabsorption was seen in both prehepatectomized and sham-hepatectomized rats. At 48 h, there was total recovery of glomerular filtration and tubular function in the prehepatectomized rats, whereas the sham-hepatectomized rats still had reduced glomerular filtration and sodium reabsorption. In rats treated with dexamethasone before hepatectomy and studied 48 h after the induction of acute renal failure, the protective action on renal function seen in prehepatectomized rats was totally blocked. A semiquantitative histological analysis done 48 h after the induction of acute renal failure demonstrated a fourfold increase in the number of necrotic tubules in both sham-hepatectomized and dexamethasone-treated rats as compared with hepatectomized rats. It is concluded that partial hepatectomy, a maneuver used to increase the endogenous synthesis of growth factors, accelerates recovery of renal function following glycerol-induced acute renal failure.
dc.description6
dc.description6
dc.description551
dc.description556
dc.languageen
dc.publisherKarger
dc.publisherBasel
dc.publisherSuíça
dc.relationExperimental Nephrology
dc.relationExp. Nephrol.
dc.rightsfechado
dc.rightshttp://www.karger.com/Services/RightsPermissions
dc.sourceWeb of Science
dc.subjectacute renal failure
dc.subjectpartial hepatectomy
dc.subjectfunctional study
dc.subjectgrowth factors
dc.subjectHepatocyte Growth-factor
dc.subjectLiver-regeneration
dc.subjectEpithelial-cells
dc.subjectC-met
dc.subjectUnilateral Nephrectomy
dc.subjectGene-expression
dc.subjectScatter Factor
dc.subjectMessenger-rna
dc.subjectDna-synthesis
dc.subjectFactor-alpha
dc.titleAccelerated recovery of glycerol-induced acute renal failure in rats with previous partial hepatectomy
dc.typeArtículos de revistas


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