Absence of mutagenic and recombinagenic activity of multi-walled carbon nanotubes in the Drosophila wing-spot test and Allium cepa test

dc.creatorde Andrade, LR
dc.creatorBrito, AS
dc.creatorMelero, AMGD
dc.creatorZanin, H
dc.creatorCeragioli, HJ
dc.creatorBaranauskas, V
dc.creatorCunha, KS
dc.creatorIrazusta, SP
dc.date2014
dc.dateJAN
dc.date2014-07-30T13:43:16Z
dc.date2015-11-26T16:32:55Z
dc.date2014-07-30T13:43:16Z
dc.date2015-11-26T16:32:55Z
dc.date.accessioned2018-03-28T23:14:32Z
dc.date.available2018-03-28T23:14:32Z
dc.identifierEcotoxicology And Environmental Safety. Academic Press Inc Elsevier Science, v. 99, n. 92, n. 97, 2014.
dc.identifier0147-6513
dc.identifier1090-2414
dc.identifierWOS:000327581800012
dc.identifier10.1016/j.ecoenv.2013.10.013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54015
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54015
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270686
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn order to assess the safety of the carbon nanotubes to human health and the environment, we investigated the potential toxicity and ability of multi-walled carbon nanotubes (NT), to induce DNA damage by employing the Allium cepa genotoxicity/mutagenicity test and the Somatic Mutation and Recombination Test (SMART) in the fruitfly, Drosophila melanogaster. The results demonstrated that NT did not significantly induce genotoxic or mutagenic effects in the Allium cepa test. All concentrations evaluated in the SMART assay showed survival rates higher than 90 percent, indicating the absence of chronic toxicity for NT. Furthermore, the various treatments showed no significant increase in the NT mutation and recombination frequencies in mwh/flr(3) genotype compared to respective negative controls, demonstrating the absence of DNA damage caused by NT. (C) 2013 Elsevier Inc. All rights reserved.
dc.description99
dc.description92
dc.description97
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherAcademic Press Inc Elsevier Science
dc.publisherSan Diego
dc.publisherEUA
dc.relationEcotoxicology And Environmental Safety
dc.relationEcotox. Environ. Safe.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectNanoparticles
dc.subjectRecombination
dc.subjectMutation
dc.subjectGenotoxicity
dc.subjectEpithelial-cells
dc.subjectOxide Nanoparticles
dc.subjectSomatic Mutation
dc.subjectOxidative Stress
dc.subjectDna-damage
dc.subjectIn-vitro
dc.subjectGenotoxicity
dc.subjectNanomaterials
dc.subjectExposure
dc.subjectFrequencies
dc.titleAbsence of mutagenic and recombinagenic activity of multi-walled carbon nanotubes in the Drosophila wing-spot test and Allium cepa test
dc.typeArtículos de revistas


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