Absence of mutations in the homeodomain of the MSX1 gene in patients with hypodontia

dc.creatorScarel, RM
dc.creatorTrevilatto, PC
dc.creatorDi Hipolito, O
dc.creatorCamargo, LEA
dc.creatorLine, SRP
dc.date2000
dc.date43617
dc.date2014-07-30T13:43:16Z
dc.date2015-11-26T16:32:53Z
dc.date2014-07-30T13:43:16Z
dc.date2015-11-26T16:32:53Z
dc.date.accessioned2018-03-28T23:14:30Z
dc.date.available2018-03-28T23:14:30Z
dc.identifierAmerican Journal Of Medical Genetics. Wiley-liss, v. 92, n. 5, n. 346, n. 349, 2000.
dc.identifier0148-7299
dc.identifierWOS:000087267400010
dc.identifier10.1002/1096-8628(20000619)92:5<346
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54016
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54016
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270678
dc.descriptionHypodontia, the congenital absence of one or a few permanent teeth, is one of the most frequent alterations of the human dentition, Although hypodontia does not represent a public health problem, it may cause both speech and masticatory dysfunction and esthetic problems. A missense mutation in the homeodomain of MSX1 gene has been associated with hypodontia of second premolars and third molars in humans. However, another study excluded this gene as causative locus for hypodontia of incisors and premolars, To further investigate the role of the MSX1 gene in human hypodontia, we analyzed the homeobox region of the MSX1 gene in 20 individuals with different patterns of familial or isolated hypodontia, The direct sequencing of PCR products did not show any polymorphisms or mutations in the human MSX1 gene, Our results indicate that inactivation of MSX1 gene in humans must have a highly selective effect on dentition, and other genes must be involved in the cause of hypodontia in humans. Am. J. Med. Genet. 92:346-349, 2000. (C) 2000 Wiiey-Liss, Inc.
dc.description92
dc.description5
dc.description346
dc.description349
dc.languageen
dc.publisherWiley-liss
dc.publisherNew York
dc.publisherEUA
dc.relationAmerican Journal Of Medical Genetics
dc.relationAm. J. Med. Genet.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectMSX1
dc.subjecthomeobox
dc.subjecthypodontia
dc.subjecttooth agenesis
dc.subjectTooth
dc.subjectAnomalies
dc.subjectDentition
dc.titleAbsence of mutations in the homeodomain of the MSX1 gene in patients with hypodontia
dc.typeArtículos de revistas


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