Parathyroid hormone (1-34) compensates the negative effect of smoking around implants

dc.creatorLima, LL
dc.creatorNeto, JBC
dc.creatorCayana, EG
dc.creatorNociti, FH
dc.creatorSallum, EA
dc.creatorCasati, MZ
dc.date2013
dc.dateSEP
dc.date2014-07-30T14:30:43Z
dc.date2015-11-26T16:32:47Z
dc.date2014-07-30T14:30:43Z
dc.date2015-11-26T16:32:47Z
dc.date.accessioned2018-03-28T23:14:21Z
dc.date.available2018-03-28T23:14:21Z
dc.identifierClinical Oral Implants Research. Wiley-blackwell, v. 24, n. 9, n. 1055, n. 1059, 2013.
dc.identifier0905-7161
dc.identifierWOS:000322203500015
dc.identifier10.1111/j.1600-0501.2012.02502.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59063
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59063
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270639
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionObjectives: This study aimed to investigate the effect of Recombinant Human Parathyroid Hormone (PTH 1-34) on attenuating the influence of cigarette smoke on bone around titanium implants. Material and methods: Forty-eight female Wistar rats were used. At the begging of the study, 15 animals were randomly assigned to Group 1 (control) and received subcutaneous injections of saline solution, three-times/week, after implant placement. The other animals received intermittent cigarette smoke inhalation (CSI), 60 days prior and 60 days after implant placement (Al2O3-blasted titanium implants - 4.0 x 2.2 mm). After surgery, these animals were randomly assigned to: Group 2 - subcutaneous injections of saline solution, three-times/week (n = 16) and Group 3 - intermittent doses of PTH (1-34) (40 mu g/Kg), three-times/week (n = 17). Animals were sacrificed 60 days after surgery, and degree of bone-to-implant contact (BIC), bone area (BA) within the limits of the threads and proportion of mineralized tissue (PMT) adjacent to the implants (500 mu m wide zone) were separately obtained in cortical and cancellous bone. Results: Data analysis confirmed that CSI negatively affects bone around implants, as observed for BIC in cortical zone (Cohen's d (d) = -1.26) and for PMT in both zones (d = -6.09 and d = -4.46 for cortical and cancellous zones, respectively). In addition, in the presence of CSI, PTH (1-34) promoted the highest BIC in both regions and BA and PMT in cancellous bone (P < 0.05). The histometric parameter that was not influenced by both PTH and CSI (1-34) was BA in cortical bone (P > 0.05). Conclusion: In the presence of cigarette smoke, a factor related to poor bone healing and low bone density, PTH (1-34) increased bone volume around implants.
dc.description24
dc.description9
dc.description1055
dc.description1059
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [471577/2007-3]
dc.languageen
dc.publisherWiley-blackwell
dc.publisherHoboken
dc.publisherEUA
dc.relationClinical Oral Implants Research
dc.relationClin. Oral Implant. Res.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectdental implants
dc.subjectosseointegration
dc.subjectPTH
dc.subjectsmoking
dc.subjectBone-mineral Density
dc.subjectPostmenopausal Women
dc.subjectTitanium Implants
dc.subjectDental Implants
dc.subjectVitamin-d
dc.subjectRats
dc.subjectOsteoporosis
dc.subjectCessation
dc.subjectIncreases
dc.subjectMass
dc.titleParathyroid hormone (1-34) compensates the negative effect of smoking around implants
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución