Association between genetic polymorphisms in apoptosis-related genes and risk of cutaneous melanoma in women and men

dc.creatorOliveira, C
dc.creatorLourenco, GJ
dc.creatorRinck, JA
dc.creatorCintra, ML
dc.creatorMoraes, AM
dc.creatorLima, CSP
dc.date2014
dc.dateMAY
dc.date2014-07-30T13:51:12Z
dc.date2015-11-26T16:32:46Z
dc.date2014-07-30T13:51:12Z
dc.date2015-11-26T16:32:46Z
dc.date.accessioned2018-03-28T23:14:17Z
dc.date.available2018-03-28T23:14:17Z
dc.identifierJournal Of Dermatological Science. Elsevier Ireland Ltd, v. 74, n. 2, n. 135, n. 141, 2014.
dc.identifier0923-1811
dc.identifier1873-569X
dc.identifierWOS:000334987600005
dc.identifier10.1016/j.jdermsci.2013.12.010
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55038
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55038
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270625
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionBackground: The P53 Arg72Pro, MDM2 c.+309T > G, BAX c.-248G > A, and BCL2 c.-717C > A polymorphisms have variable roles in the apoptosis pathways. Objective: To clarify the roles of these polymorphisms in the risk for cutaneous melanoma (CM). Methods: Genomic DNA of 200 CM patients and 215 controls was analyzed by PCR-RFLP. Results: In women, the frequencies of BAX GG (83.0% vs. 71.0%, P = 0.04), BM AA (32.0% vs. 15.0%, P = 0.003), P53 ArgArg plus BAX GG (84.9% vs. 63.2%, P = 0.01), P53 ArgArg plus BCL2 AA (37.0% vs. 13.1%, P = 0.003), BAX GG plus BCL2 AA (70.3% vs. 33.3%, P = 0.001), MDM2 GG plus BAX GG plus BCL2 AA (27.3% vs. 3.7%, P = 0.03), and P53 ArgArg plus MDM2 GG plus BAX GG plus BCL2 AA (33.3% vs. 5.6%, P = 0.04) genotypes were higher in patients than in controls. Female carriers of the respective genotypes were under 1.98 (95% CI: 1.01-3.91), 2.87 (95% CI: 1.43-5.77), 3.48 (95% CI: 1.34-9.04), 4.23 (95% CI: 1.63-10.96), 6.04 (95% CI: 2.10-17.37), 25.61 (95% CI: 1.29-507.24), and 25.69 (95% CI: 1.11-593.59)-fold increased risks for CM than others, respectively. In men, the frequencies of BCL2 CA + AA (83.0% vs. 67.6%, P = 0.01) and MDM2 TG + GG plus BCL2 CA + AA (94.2% vs. 68.3%, P = 0.003) genotypes were higher in patients than in controls. Male carriers of the respective genotypes were under 2.43 (95% CI: 1.23-4.82) and 9.22 (95% CI: 2.16-39.31)-fold increased CM risks than others, respectively. Conclusion: The data suggest for the first time that P53 Arg72Pro, MDM2 c.+309T > G, BAX c.-248G > A, and BCL2 c.-717C > A polymorphisms, enrolled in apoptosis pathways, constitute distinct determinants of CM in women and men. (C) 2014 Japanese Society for Investigative Dermatology. Published by Elsevier Ireland Ltd. All rights reserved.
dc.description74
dc.description2
dc.description135
dc.description141
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFAPESP [2009/12602-0, 2010/18904-5]
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationJournal Of Dermatological Science
dc.relationJ. Dermatol. Sci.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectMelanoma
dc.subjectApoptosis
dc.subjectGenetic polymorphisms
dc.subjectRisk
dc.subjectSingle-nucleotide Polymorphism
dc.subjectChronic-lymphocytic-leukemia
dc.subjectMultifactor Dimensionality Reduction
dc.subjectAccelerates Tumor-formation
dc.subjectGenome-wide Association
dc.subjectEstrogen-receptor-alpha
dc.subjectBreast-cancer Cells
dc.subjectSkin-cancer
dc.subjectDna-repair
dc.subjectBax Gene
dc.titleAssociation between genetic polymorphisms in apoptosis-related genes and risk of cutaneous melanoma in women and men
dc.typeArtículos de revistas


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