dc.creator | Gueiros, LA | |
dc.creator | Coletta, RD | |
dc.creator | Kowalski, LP | |
dc.creator | Lopes, MA | |
dc.date | 2011 | |
dc.date | MAY | |
dc.date | 2014-07-30T13:59:53Z | |
dc.date | 2015-11-26T16:32:36Z | |
dc.date | 2014-07-30T13:59:53Z | |
dc.date | 2015-11-26T16:32:36Z | |
dc.date.accessioned | 2018-03-28T23:14:04Z | |
dc.date.available | 2018-03-28T23:14:04Z | |
dc.identifier | International Journal Of Oral And Maxillofacial Surgery. Churchill Livingstone, v. 40, n. 5, n. 510, n. 515, 2011. | |
dc.identifier | 0901-5027 | |
dc.identifier | WOS:000291137500010 | |
dc.identifier | 10.1016/j.ijom.2010.12.008 | |
dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56092 | |
dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/56092 | |
dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1270570 | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | The aim of this study was to evaluate the clinicopathological features and immunohistochemical expression of proliferation markers in oral tongue squamous cell carcinomas (OTSCC). Sixty-three patients without previous treatment or distant metastases were selected. Clinical information was retrieved from medical charts, histopathological analysis was performed and expression of proliferation markers (Ki-67, Mcm-2 and geminin) was evaluated. Most patients were men (81%) (male:female ratio 4.25:1). The age range was 31-92 years (mean 57.6 +/- 11.81 years). A high Anneroth score was associated with tumour size (p = 0.05), tumoural embolization of the blood vessels = 0.003), nodal metastasis (p = 0.05), nodal capsule rupture (p = 0.016) and distant metastasis (p = 0.002). Elevated Bryne scores were significantly associated with nodal capsule rupture (p = 0.02), distant metastasis (p = 0.002), shorter overall survival (OS) (p = 0.03) and disease-free survival (DFS) (p = 0.05) compared with patients with lower score. Elevated Ki-67+ cells (p = 0.05) and Mcm-2+ cells (p = 0.008) were associated with nodal metastasis and tumours with a high geminin score demonstrated a significant tendency for neural invasion (p = 0.05). Anneroth and Bryne score in association with biomarkers of proliferation can be useful for evaluating the biological behaviour of OTSCC. | |
dc.description | 40 | |
dc.description | 5 | |
dc.description | 510 | |
dc.description | 515 | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
dc.language | en | |
dc.publisher | Churchill Livingstone | |
dc.publisher | Edinburgh | |
dc.publisher | Escócia | |
dc.relation | International Journal Of Oral And Maxillofacial Surgery | |
dc.relation | Int. J. Oral Maxillofac. Surg. | |
dc.rights | fechado | |
dc.source | Web of Science | |
dc.subject | tongue neoplasms | |
dc.subject | cell proliferation | |
dc.subject | biological marker | |
dc.subject | histological grading | |
dc.subject | Minichromosome Maintenance Protein-2 | |
dc.subject | High Prognostic Value | |
dc.subject | Deep Invasive Front | |
dc.subject | Oral Tongue | |
dc.subject | Stage-i | |
dc.subject | Expression | |
dc.subject | Cancer | |
dc.subject | Ki-67 | |
dc.subject | Geminin | |
dc.subject | Cavity | |
dc.title | Clinicopathological features and proliferation markers in tongue squamous cell carcinomas | |
dc.type | Artículos de revistas | |