Clinicopathological features and proliferation markers in tongue squamous cell carcinomas

dc.creatorGueiros, LA
dc.creatorColetta, RD
dc.creatorKowalski, LP
dc.creatorLopes, MA
dc.date2011
dc.dateMAY
dc.date2014-07-30T13:59:53Z
dc.date2015-11-26T16:32:36Z
dc.date2014-07-30T13:59:53Z
dc.date2015-11-26T16:32:36Z
dc.date.accessioned2018-03-28T23:14:04Z
dc.date.available2018-03-28T23:14:04Z
dc.identifierInternational Journal Of Oral And Maxillofacial Surgery. Churchill Livingstone, v. 40, n. 5, n. 510, n. 515, 2011.
dc.identifier0901-5027
dc.identifierWOS:000291137500010
dc.identifier10.1016/j.ijom.2010.12.008
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/56092
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/56092
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270570
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionThe aim of this study was to evaluate the clinicopathological features and immunohistochemical expression of proliferation markers in oral tongue squamous cell carcinomas (OTSCC). Sixty-three patients without previous treatment or distant metastases were selected. Clinical information was retrieved from medical charts, histopathological analysis was performed and expression of proliferation markers (Ki-67, Mcm-2 and geminin) was evaluated. Most patients were men (81%) (male:female ratio 4.25:1). The age range was 31-92 years (mean 57.6 +/- 11.81 years). A high Anneroth score was associated with tumour size (p = 0.05), tumoural embolization of the blood vessels = 0.003), nodal metastasis (p = 0.05), nodal capsule rupture (p = 0.016) and distant metastasis (p = 0.002). Elevated Bryne scores were significantly associated with nodal capsule rupture (p = 0.02), distant metastasis (p = 0.002), shorter overall survival (OS) (p = 0.03) and disease-free survival (DFS) (p = 0.05) compared with patients with lower score. Elevated Ki-67+ cells (p = 0.05) and Mcm-2+ cells (p = 0.008) were associated with nodal metastasis and tumours with a high geminin score demonstrated a significant tendency for neural invasion (p = 0.05). Anneroth and Bryne score in association with biomarkers of proliferation can be useful for evaluating the biological behaviour of OTSCC.
dc.description40
dc.description5
dc.description510
dc.description515
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherChurchill Livingstone
dc.publisherEdinburgh
dc.publisherEscócia
dc.relationInternational Journal Of Oral And Maxillofacial Surgery
dc.relationInt. J. Oral Maxillofac. Surg.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecttongue neoplasms
dc.subjectcell proliferation
dc.subjectbiological marker
dc.subjecthistological grading
dc.subjectMinichromosome Maintenance Protein-2
dc.subjectHigh Prognostic Value
dc.subjectDeep Invasive Front
dc.subjectOral Tongue
dc.subjectStage-i
dc.subjectExpression
dc.subjectCancer
dc.subjectKi-67
dc.subjectGeminin
dc.subjectCavity
dc.titleClinicopathological features and proliferation markers in tongue squamous cell carcinomas
dc.typeArtículos de revistas


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