Assessment of the value of detecting specific IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection

dc.creatorNascimento, FS
dc.creatorSuzuki, LA
dc.creatorRossi, CL
dc.date2008
dc.dateAUG
dc.date2014-11-16T23:48:45Z
dc.date2015-11-26T16:32:31Z
dc.date2014-11-16T23:48:45Z
dc.date2015-11-26T16:32:31Z
dc.date.accessioned2018-03-28T23:13:56Z
dc.date.available2018-03-28T23:13:56Z
dc.identifierPrenatal Diagnosis. John Wiley & Sons Ltd, v. 28, n. 8, n. 749, n. 752, 2008.
dc.identifier0197-3851
dc.identifierWOS:000258649100011
dc.identifier10.1002/pd.2052
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55020
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55020
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55020
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270538
dc.descriptionObjective To assess the value of detecting IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection. Methods IgA antibodies were screened in sera from 87 women with different serological profiles of Toxoplasma gondii IgM and IgG antibodies and Toxoplasma-specific IgG avidity. The IgM and IgG antibodies and the IgG avidity were measured with an automated Vitek Immuno Diagnostic Assay System (VIDAS). Anti-T.gondii IgA was measured with Platelia Toxo IgA TMB kits. Results All 12 sera obtained from women with clinical and/or serological evidence of recently acquired Toxoplasma infection were positive for IgA. In 42 serum samples obtained more than 6 months after T. gondii infection from women wiht no clinical evidence of infection, but who had a positive IgM test and a high IgG avidity index, the IgA-enzyme linked immunosorbent assay (ELISA) test results were positive, negative, and doubtful in 16 (38.1%), 23 (54.85), and 3 (7.1%) sera, respectively. In eight women, IgA was detected in sera collected more than 9 months after the onset of infection. The IgA test result was also positive in 11 of 12 sera (91.7%) obtained from women with no clinical evidence of toxoplasmosis, but who had a positive IgM test and a borderline IgG avidity index. The IgA-ELISA was negative in 21 sera obtained more than 2 years after the onset of T. gondii infection from women with no clinical evidence of toxoplasmosis, but who had a negative IgM test and a positive IgG test. Conclusion These results show that IgA is not a dependable marker for a recently acquired primary Toxoplasma infection. Copyright (C) 2008 John Wiley & sons, Ltd.
dc.description28
dc.description8
dc.description749
dc.description752
dc.languageen
dc.publisherJohn Wiley & Sons Ltd
dc.publisherChichester
dc.publisherInglaterra
dc.relationPrenatal Diagnosis
dc.relationPrenat. Diagn.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjecttoxoplasmosis
dc.subjectserological diagnosis
dc.subjectIgA
dc.subjectImmunoglobulin-a Detection
dc.subjectPregnant-women
dc.subjectClinical Toxoplasmosis
dc.subjectAvidity
dc.subjectAssay
dc.subjectGondii
dc.subjectMarkers
dc.subjectBrazil
dc.titleAssessment of the value of detecting specific IgA antibodies for the diagnosis of a recently acquired primary Toxoplasma infection
dc.typeArtículos de revistas


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