Therapeutic potential of biogenic silver nanoparticles in murine cutaneous leishmaniasis

dc.creatorRossi-Bergmann, B
dc.creatorPacienza-Lima, W
dc.creatorMarcato, PD
dc.creatorDe Conti, R
dc.creatorDuran, N
dc.date2012
dc.date2014-07-30T14:06:04Z
dc.date2015-11-26T16:32:21Z
dc.date2014-07-30T14:06:04Z
dc.date2015-11-26T16:32:21Z
dc.date.accessioned2018-03-28T23:13:46Z
dc.date.available2018-03-28T23:13:46Z
dc.identifierJournal Of Nano Research. Trans Tech Publications Ltd, v. 20, n. 89, n. 97, 2012.
dc.identifier1662-5250
dc.identifierWOS:000313760400010
dc.identifier10.4028/www.scientific.net/JNanoR.20.89
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/57963
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/57963
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270490
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionIn the last years, silver nanoparticles have appeared as novel antimicrobial agents. In this work, we evaluated the therapeutic potential of silver nanoparticles prepared by two different processes: 1) chemical synthesis (Chem-AgNP); and 2) biosynthesis from the fungus Fusarium oxysporum (Bio-AgNP), in the treatment of cutaneous leishmaniasis. When tested in vitro against Leishmania amazonensis promastigotes, Bio-AgNP was 4-fold more potent than Chem-AgNP (IC50 = 25 uM and 100 uM, respectively). In vivo studies in mice infected in the ear showed that bi-weekly intralesional injections with only 6.5 ug/Kg of body weight of Bio-AgNP during 4 weeks were equally effective as 300-fold higher doses of the reference drug amphotericin B, and more effective than 3-fold higher doses of Chem-AgNP. Contrary to the hepato- and nephrotoxicity that resulted from amphotericin B treatment, and the slight hepatotoxicity produced by Chem-AgNP, no changes in serum levels of AST, ALT and creatinine were detected with Bio-AgNP. Together, these findings show that the biogenic synthesis resulted in enhanced in vitro and in vivo antileishmanial activities, and safer silver nanoparticles as compared with the chemical synthesis.
dc.description20
dc.description89
dc.description97
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherTrans Tech Publications Ltd
dc.publisherStafa-zuerich
dc.publisherSuíça
dc.relationJournal Of Nano Research
dc.relationJ. Nano Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectLeaishmaniasis
dc.subjectbiogenic
dc.subjectsilver nanoparticles
dc.subjectin vivo
dc.titleTherapeutic potential of biogenic silver nanoparticles in murine cutaneous leishmaniasis
dc.typeArtículos de revistas


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