A silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro

dc.creatorCarvalho, MA
dc.creatorde Paiva, REF
dc.creatorBergamini, FRG
dc.creatorGomes, AF
dc.creatorGozzo, FC
dc.creatorLustri, WR
dc.creatorFormiga, ALB
dc.creatorShishido, SM
dc.creatorFerreira, CV
dc.creatorCorbi, PP
dc.date2013
dc.date42370
dc.date2014-07-30T13:42:50Z
dc.date2015-11-26T16:31:33Z
dc.date2014-07-30T13:42:50Z
dc.date2015-11-26T16:31:33Z
dc.date.accessioned2018-03-28T23:12:38Z
dc.date.available2018-03-28T23:12:38Z
dc.identifierJournal Of Molecular Structure. Elsevier Science Bv, v. 1031, n. 125, n. 131, 2013.
dc.identifier0022-2860
dc.identifierWOS:000312686000018
dc.identifier10.1016/j.molstruc.2012.07.044
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53753
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53753
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270251
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe synthesis, spectroscopic characterization and biological assays of a new silver(I) complex with L-tryptophan (TRP) are presented. Elemental and thermal analyses and ESI-QTOF mass spectrometric measurements of the solid compound suggest the composition AgC11H11N2O2. Infrared and solid-state NMR analyses indicate coordination of TRP to Ag(I) ion through the nitrogen of the NH2 group and also through the oxygen of carboxylate group. Theoretical (DFT) calculations permit proposing an optimized geometry for the complex. Antibacterial assays indicated that the Ag-TRP complex is effective against Staphylococcus aureus and Enterococcus faecalis (Gram-positive), and Pseudomonas aeruginosa and Escherichia coli (Gram-negative) bacterial strains. The complex was also cytotoxic against Panc-1 (human pancreatic carcinoma) and SK-Mel 103 (human melanoma) cells. (C) 2012 Elsevier B.V. All rights reserved.
dc.description1031
dc.description125
dc.description131
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [2006/55367-2, 2012/08230-2, 2008/57805-2]
dc.descriptionCNPq [573672/2008-3, 472468/2010-3, 472067/2010-9]
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationJournal Of Molecular Structure
dc.relationJ. Mol. Struct.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectL-tryptophan
dc.subjectSilver
dc.subjectSolid-state NMR
dc.subjectESI-QTOF mass spectrometry
dc.subjectAntibacterial agent
dc.subjectAntitumoral assays
dc.subjectMolecular-orbital Methods
dc.subjectGaussian-type Basis
dc.subjectAntimicrobial Activities
dc.subjectCrystal-structures
dc.subjectTriphenylphosphine Ligands
dc.subjectPalladium(ii) Complex
dc.subjectOrganic-molecules
dc.subjectSolid-state
dc.subjectDensity
dc.subjectPotentials
dc.titleA silver complex with tryptophan: Synthesis, structural characterization, DFT studies and antibacterial and antitumor assays in vitro
dc.typeArtículos de revistas


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