The role of magnesium in the endothelial dysfunction caused by global ischemia followed by reperfusion: in vitro study of canine coronary arteries

dc.creatorVolpe, MA
dc.creatorCarneiro, JJ
dc.creatorMagna, LA
dc.creatorViaro, F
dc.creatorOriguela, EAL
dc.creatorEvora, PRB
dc.date2003
dc.dateSEP
dc.date2014-11-16T01:15:40Z
dc.date2015-11-26T16:31:21Z
dc.date2014-11-16T01:15:40Z
dc.date2015-11-26T16:31:21Z
dc.date.accessioned2018-03-28T23:12:23Z
dc.date.available2018-03-28T23:12:23Z
dc.identifierScandinavian Cardiovascular Journal. Taylor & Francis As, v. 37, n. 5, n. 288, n. 296, 2003.
dc.identifier1401-7431
dc.identifierWOS:000185766500009
dc.identifier10.1080/14017430310014939
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/72387
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/72387
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/72387
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270181
dc.descriptionObjective-To study the role of magnesium in the endothelial dysfunction of canine coronary arteries caused by cardiopulmonary bypass (CPB) global ischemia followed by reperfusion. Design-Segments of canine coronary arteries were suspended in organ chambers to measure isometric contraction by prostaglandin F-2alpha, and relaxed by acetylcholine (ACh), sodium fluoride (NaF), calcium ionophore (A(23187)) and sodium nitroprusside (SNP) in crescent concentrations. The investigation protocol had groups with six dogs: CONTROL group (without CPB), CPB group (105 min of CPB without aortic cross-clamping), ISCH group (45 min of CPB with aortic cross-clamping), ISCH/REP group (45 min of aortic cross-clamping followed by 60 min of reperfusion). The coronary relaxations were evaluated with (phase I), without (phase II) and restored magnesium (phase III) to the organ bath. Results-The presence of magnesium in the organ bath was associated with the greater relaxation in response to agonists of the nitric oxide production. The removal of magnesium from the organ bath was associated with the reduction in the intensity of vessel relaxation. The magnesium restoration to the organ bath was associated with the additional reduction in the intensity of relaxation with the exception of NaF that allowed reacquisition of the relaxation observed in the presence of magnesium. Conclusion-This in vitro study demonstrates that magnesium ion favorably influences the nitric oxide production by the coronary endothelium, attenuating the endothelial dysfunction caused by global ischemia followed by reperfusion.
dc.description37
dc.description5
dc.description288
dc.description296
dc.languageen
dc.publisherTaylor & Francis As
dc.publisherOslo
dc.publisherNoruega
dc.relationScandinavian Cardiovascular Journal
dc.relationScand. Cardiovasc. J.
dc.rightsfechado
dc.rightshttp://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp
dc.sourceWeb of Science
dc.subjectcoronary reperfusion
dc.subjectendothelium
dc.subjectG-proteins
dc.subjectischemia
dc.subjectmagnesium
dc.subjectnitric oxide
dc.subjectAcute Myocardial-infarction
dc.subjectIntervention-trial Limit-2
dc.subjectDependent Relaxation
dc.subjectBlood Cardioplegia
dc.subjectSulfate
dc.subjectFluoride
dc.subjectRelease
dc.subjectCalcium
dc.subjectBypass
dc.subjectInjury
dc.titleThe role of magnesium in the endothelial dysfunction caused by global ischemia followed by reperfusion: in vitro study of canine coronary arteries
dc.typeArtículos de revistas


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