Pharmacokinetic profile of atenolol aspirinate

dc.creatorMontes-Gil, AC
dc.creatorZanfolin, M
dc.creatorOkuyama, CE
dc.creatorLilla, S
dc.creatorAlves, DP
dc.creatorSantagada, V
dc.creatorPerissutti, E
dc.creatorLavecchia, A
dc.creatorFiorino, F
dc.creatorSeverino, B
dc.creatorCaliendo, G
dc.creatorPriviero, FBM
dc.creatorMendes, GD
dc.creatorDonato, JL
dc.creatorde Nucci, G
dc.date2007
dc.dateSEP
dc.date2014-11-16T01:21:11Z
dc.date2015-11-26T16:31:19Z
dc.date2014-11-16T01:21:11Z
dc.date2015-11-26T16:31:19Z
dc.date.accessioned2018-03-28T23:12:21Z
dc.date.available2018-03-28T23:12:21Z
dc.identifierArchiv Der Pharmazie. Wiley-v C H Verlag Gmbh, v. 340, n. 9, n. 445, n. 455, 2007.
dc.identifier0365-6233
dc.identifierWOS:000249747700001
dc.identifier10.1002/ardp.200700070
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59398
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/59398
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59398
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270175
dc.descriptionWe report microwave-assisted synthetic routes, the pharmacokinetic profile along with results from ulcerogenicity and mutagenicity studies of atenolol aspirinate, and an already described derivative, in which acetyl salicylic acid (aspiring) was connected to atenolol by an ester linkage. Atenolol aspirinate was stable towards aqueous hydrolysis but rapidly hydrolyzed in plasma (t(1/2) = 7.6 min). The results showed that the rapid and complete hydrolysis generates atenolol salicylate, which assumes a conformation stabilized by two intramolecular H-bonds, avoiding its further hydrolysis to salicylic acid and atenolol.
dc.description340
dc.description9
dc.description445
dc.description455
dc.languageen
dc.publisherWiley-v C H Verlag Gmbh
dc.publisherWeinheim
dc.publisherAlemanha
dc.relationArchiv Der Pharmazie
dc.relationArch. Pharm.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectantihypertensive therapy
dc.subjectatenolol
dc.subjectmicrowave synthesis
dc.subjectpharmacokinetics
dc.subjectprodrug
dc.subjectNitric-oxide Synthesis
dc.subjectDrug Discovery
dc.subjectCardiomyocyte Hypertrophy
dc.subjectMyocardial-infarction
dc.subjectAntiplatelet Therapy
dc.subjectSynthetic Procedure
dc.subjectRandomized Trials
dc.subjectIn-vitro
dc.subjectHypertension
dc.subjectInhibition
dc.titlePharmacokinetic profile of atenolol aspirinate
dc.typeArtículos de revistas


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