Drug Release from Microspheres and Nanospheres of Poly(lactide-co-glycolide) without Sphere Separation from the Release Medium

dc.creatorda Silva, AR
dc.creatorZaniquelli, MED
dc.creatorBaratti, MO
dc.creatorJorge, RA
dc.date2010
dc.date2014-11-16T01:23:30Z
dc.date2015-11-26T16:31:18Z
dc.date2014-11-16T01:23:30Z
dc.date2015-11-26T16:31:18Z
dc.date.accessioned2018-03-28T23:12:20Z
dc.date.available2018-03-28T23:12:20Z
dc.identifierJournal Of The Brazilian Chemical Society. Soc Brasileira Quimica, v. 21, n. 2, n. 214, n. 225, 2010.
dc.identifier0103-5053
dc.identifierWOS:000276085500005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/63504
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/63504
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/63504
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270169
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionA new technique using diffuse reflectance spectroscopy was developed that enables the monitoring of encapsulated drug release without particle separation from the assayed medium. Studies of chloro(5,10,15,20-tetraphenylporphyrinato)indium(III) (InTPP) release from microspheres and nanospheres of poly(lactide-co-glycolide) (PLGA) were performed using this new technique. The release of InTPP was biphasic, with an initial fast release followed by a second slower release. Mathematical models applied to the release profiles showed that the release of InTPP from the nanospheres was controlled by diffusion, which is to be expected for a substance homogeneously dispersed within the spheres. However, due to the large size distribution of the microspheres loaded with InTPP, the release profiles were irregular, hampering an adequate fit to mathematical models. Confocal analysis of microparticles showed that the InTPP appeared to be homogenously distributed within the microspheres and no preferential distribution of InTPP towards the interior or towards the surface of the spheres was observed.
dc.description21
dc.description2
dc.description214
dc.description225
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionUniversidade Estadual de Campinas
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherSoc Brasileira Quimica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationJournal Of The Brazilian Chemical Society
dc.relationJ. Braz. Chem. Soc.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectchloro(5,10,15,20-tetraphenylporphyrinato)indium(III)
dc.subjectnanospheres
dc.subjectmicrospheres
dc.subjectdrug release
dc.subjectpoly(lactide-co-glycolide)
dc.subjectLoaded Biodegradable Nanospheres
dc.subjectPhotodynamic Therapy
dc.subjectIn-vitro
dc.subjectPhotosensitizing Efficacy
dc.subjectSolvent Evaporation
dc.subjectPlga Nanoparticles
dc.subjectPolyvinyl-alcohol
dc.subjectCentral Metal
dc.subjectDelivery
dc.subjectNanoprecipitation
dc.titleDrug Release from Microspheres and Nanospheres of Poly(lactide-co-glycolide) without Sphere Separation from the Release Medium
dc.typeArtículos de revistas


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