Artículos de revistas
Influence of the glutathione s-transferase gene polymorphisms on the susceptibility to basal cell skin carcinoma
Registro en:
Revista Medica De Chile. Soc Medica Santiago, v. 135, n. 3, n. 301, n. 306, 2007.
0034-9887
WOS:000246219100004
Autor
Leite, JL
Morari, EC
Granja, F
Campos, GM
Guilhen, ACT
Ward, LS
Institución
Resumen
Background: The identification of groups at high risk in fundamental to determine preventive strategies for skin cancer. Destructive reactive oxygen species produced by UVA or chemical carcinogens are metabolized by a series of enzymes. Polymorphisms of genes encoding for these enzymes may produce defective proteins with a diminished ability to detoxify a wide range of carcinogens. Aims: To ascertain the influence and potential interactions of several polymorphisms of genes encoding four important antioxidant GST enzymes in the susceptibility to cancer among Brazilians. Material and methods: We compared the genotypes of Glutathione S-Transferase mu, theta, pi and omega (GSTM1, GSTT1, GSTP1 and GSTO2) in a group of 102 patients with skin lesions and 124 controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls. Results: Patients with Basal Cell Skin Carcinoma (BCC) presented the combined GSTM1-GSTT1+ genotype more frequently (49.1%) than controls (20.8%) (Fisher test, p = 0.04), conferring a 2.273 (Odds Ratio; 95% CI = 1.199-4.308) higher risk for BCC. We were not able to find any other association between genotypes or between any genotype and the patients' clinical features. Conclusions: The GST profile may help identify Brazilian individuals at higher risk for BCC. 135 3 301 306