Prilocaine-cyclodextrin-liposome: effect of pH variations on the encapsulation and topology of a ternary complex using H-1 NMR

dc.creatorCabeca, LF
dc.creatorFigueiredo, IM
dc.creatorde Paula, E
dc.creatorMarsaioli, AJ
dc.date2011
dc.dateJUN
dc.date2014-07-30T18:08:14Z
dc.date2015-11-26T16:30:47Z
dc.date2014-07-30T18:08:14Z
dc.date2015-11-26T16:30:47Z
dc.date.accessioned2018-03-28T23:11:50Z
dc.date.available2018-03-28T23:11:50Z
dc.identifierMagnetic Resonance In Chemistry. Wiley-blackwell, v. 49, n. 6, n. 295, n. 300, 2011.
dc.identifier0749-1581
dc.identifierWOS:000291114500001
dc.identifier10.1002/mrc.2740
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70264
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70264
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1270050
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionA better comprehension of the prilocaine (PLC)-beta-cyclodextrin (beta-CD) complex liberation to membranes was provided by studying the architectural supramolecular arrangements of PLC, beta-CD and egg phosphatidylcholine (EPC) liposomes, a membrane model. The topologies and possible interactions of mixtures of PLC, beta-CD and EPC liposomes were investigated by nuclear magnetic resonances combining experimental H-1-NMR (1D ROESY, STD and DOSY) at different pHs. The results indicate that in the mixture PLC/beta-CD/EPC at pH 10 the PLC molecules are almost totally embedded into the liposomes and little interaction was observed between PLC and beta-CD. However, at pH 5.5 not only was PLC imbedded in the EPC bilayer, but PLC was also interacting with beta-CD. These results were rationalized as a spontaneous PLC release from beta-CD to liposomes vesicles, whereas the PLC/EPC complex formation was higher at pH 10 than pH 5.5. Copyright (C) 2011 John Wiley & Sons, Ltd.
dc.description49
dc.description6
dc.description295
dc.description300
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionANP
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationMagnetic Resonance In Chemistry
dc.relationMagn. Reson. Chem.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectNMR
dc.subjectH-1
dc.subject1D ROESY
dc.subjectDOSY
dc.subjectSTD
dc.subjectprilocaine
dc.subjectcyclodextrins
dc.subjectliposome
dc.subjectNuclear-magnetic-resonance
dc.subjectTransfer Difference Nmr
dc.subjectLigand-binding
dc.subjectStd Nmr
dc.subjectIn-vivo
dc.subjectSpectroscopy
dc.subjectDiffusion
dc.subjectRelease
dc.subjectDrugs
dc.subjectFate
dc.titlePrilocaine-cyclodextrin-liposome: effect of pH variations on the encapsulation and topology of a ternary complex using H-1 NMR
dc.typeArtículos de revistas


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