| dc.creator | Silva, KC | |
| dc.creator | Rosales, MAB | |
| dc.creator | de Faria, JBL | |
| dc.creator | de Faria, JML | |
| dc.date | 2010 | |
| dc.date | JUN | |
| dc.date | 2014-11-15T03:42:57Z | |
| dc.date | 2015-11-26T16:30:42Z | |
| dc.date | 2014-11-15T03:42:57Z | |
| dc.date | 2015-11-26T16:30:42Z | |
| dc.date.accessioned | 2018-03-28T23:11:44Z | |
| dc.date.available | 2018-03-28T23:11:44Z | |
| dc.identifier | Current Eye Research. Taylor & Francis Inc, v. 35, n. 6, n. 519, n. 528, 2010. | |
| dc.identifier | 0271-3683 | |
| dc.identifier | WOS:000282896300012 | |
| dc.identifier | 10.3109/02713681003664923 | |
| dc.identifier | http://www.repositorio.unicamp.br/jspui/handle/REPOSIP/80336 | |
| dc.identifier | http://www.repositorio.unicamp.br/handle/REPOSIP/80336 | |
| dc.identifier | http://repositorio.unicamp.br/jspui/handle/REPOSIP/80336 | |
| dc.identifier.uri | http://repositorioslatinoamericanos.uchile.cl/handle/2250/1270025 | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Purpose: To investigate if nitric oxide (NO) system contributes to the beneficial effect of angiotensin II type 1 receptor (AT 1) blocker losartan in the retina of diabetic spontaneously hypertensive rats (SHR). Methods: Diabetic SHR were randomized to receive oral treatment with losartan (DM-SHRLos). After 20 days, the rats were euthanized and the retinas collected. Results: Diabetic SHR rats exhibited a significant increase in glial fibrillary acidic protein (GFAP) and decrease in occludin, markers of early diabetic retinopathy (DR). The oxidative status, evaluated by NO end-products (NO(x)(-)) levels along with the antioxidative system superoxide dismutase, revealed an accentuated imbalance in favor to oxidants in DM-SHR leading to a higher tyrosine nitration and DNA damage. The inducible NO synthase (iNOS) was also elevated in DM-SHR rats. The treatment with losartan ameliorated all of the above alterations. Conclusions: Oral treatment with losartan reduces iNOS expression and reestablishes the redox status, thus ameliorating the early markers of DR in a model of diabetes and hypertension. | |
| dc.description | 35 | |
| dc.description | 6 | |
| dc.description | 519 | |
| dc.description | 528 | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) | |
| dc.description | Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) | |
| dc.description | FAPESP [05/58189-5, 08/54068-7] | |
| dc.language | en | |
| dc.publisher | Taylor & Francis Inc | |
| dc.publisher | Philadelphia | |
| dc.publisher | EUA | |
| dc.relation | Current Eye Research | |
| dc.relation | Curr. Eye Res. | |
| dc.rights | fechado | |
| dc.rights | http://journalauthors.tandf.co.uk/permissions/reusingOwnWork.asp | |
| dc.source | Web of Science | |
| dc.subject | Angiotension II type 1 receptor blocker | |
| dc.subject | Diabetic retinopathy | |
| dc.subject | Inducible nitric oxide synthase | |
| dc.subject | Nitric oxide end products | |
| dc.subject | Oxidative stress | |
| dc.subject | Endothelial Growth-factor | |
| dc.subject | Intercellular-adhesion Molecule-1 | |
| dc.subject | Factor-kappa-b | |
| dc.subject | Poly(adp-ribose) Polymerase | |
| dc.subject | At(1) Receptor | |
| dc.subject | Cerebral-ischemia | |
| dc.subject | In-vivo | |
| dc.subject | Retinopathy | |
| dc.subject | Stress | |
| dc.subject | Expression | |
| dc.title | Reduction of Inducible Nitric Oxide Synthase via Angiotensin Receptor Blocker Prevents the Oxidative Retinal Damage in Diabetic Hypertensive Rats | |
| dc.type | Artículos de revistas | |
