Nicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens

dc.creatorSchmidt, BL
dc.creatorTambeli, CH
dc.creatorGear, RW
dc.creatorLevine, JD
dc.date2001
dc.date2014-11-15T02:09:35Z
dc.date2015-11-26T16:30:24Z
dc.date2014-11-15T02:09:35Z
dc.date2015-11-26T16:30:24Z
dc.date.accessioned2018-03-28T23:11:29Z
dc.date.available2018-03-28T23:11:29Z
dc.identifierNeuroscience. Pergamon-elsevier Science Ltd, v. 106, n. 1, n. 129, n. 136, 2001.
dc.identifier0306-4522
dc.identifierWOS:000171242700013
dc.identifier10.1016/S0306-4522(01)00264-0
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81970
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/81970
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81970
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269956
dc.descriptionThe nucleus accumbens, as part of the mesolimbic dopaminergic reward pathway, mediates both addiction to and withdrawal from substances of abuse. In addition, activity of substances of abuse such as opioids in the nucleus accumbens has been implicated in pain modulation. Because nucleus accumbens nicotinic receptors are important in nicotine addiction and because nicotinic activity can interact with opioid action, we investigated the contribution of nucleus accumbens nicotinic receptors to opioid-mediated analgesia/antinociception. The response of the nociceptive jaw-opening reflex to opioids was studied in the rat, both before and during chronic nicotine exposure. In nicotine-naive rats, intra-accumbens injection of the nicotinic receptor antagonist mecamylamine blocked antinociception produced by either systemic morphine, intra-accumbens co-administration of a mu- and a delta -opioid receptor agonist, or noxious stimulation (i.e., subdermal capsaicin in the hindpaw); intra-accumbens mecamylamine alone had no effect. The antinociceptive effect of either morphine or noxious stimulation was unchanged during nicotine tolerance; however, intra-accumbens mecamylamine lost its ability to block antinociception produced by either treatment. Intra-accumbens mecamwylamine by itself precipitated significant hyperalgesia in nicotine-tolerant rats which could be suppressed by noxious stimulation as well as by morphine. These results indicate that nucleus accumbens nicotinic receptors play an important role in both opioid- and noxious stimulus-induced antinociception in nicotine-naive rats. This role was attenuated in the nicotine-dependent state. The suppression of withdrawal hyperalgesia by noxious stimulation suggests that pain can ameliorate the symptoms of withdrawal, thus suggesting a possible mechanism for pain-seeking behavior. (C) 2001 IBRO. Published by Elsevier Science Ltd. All rights reserved.
dc.description106
dc.description1
dc.description129
dc.description136
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationNeuroscience
dc.relationNeuroscience
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectwithdrawal hyperalgesia
dc.subjectantinociception
dc.subjectnucleus accumbens
dc.subjectmorphine
dc.subjectnicotine tolerance
dc.subjectpain-induced analgesia
dc.subjectSelf-injurious-behavior
dc.subjectVentral Tegmental Area
dc.subjectAbstinence Syndrome
dc.subjectBrain Sites
dc.subjectRat
dc.subjectDopamine
dc.subjectMorphine
dc.subjectSmoking
dc.subjectAntinociception
dc.subjectMechanisms
dc.titleNicotine withdrawal hyperalgesia and opioid-mediated analgesia depend on nicotine receptors in nucleus accumbens
dc.typeArtículos de revistas


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