Geranylgeraniol and 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oate methyl ester isolated from Pterodon pubescens Benth.: Further investigation on the antinociceptive mechanisms of action

dc.creatorSpindola, HM
dc.creatorServat, L
dc.creatorRodrigues, RAF
dc.creatorSousa, IMO
dc.creatorCarvalho, JE
dc.creatorFoglio, MA
dc.date2011
dc.dateAPR 10
dc.date2014-07-30T17:47:55Z
dc.date2015-11-26T16:29:59Z
dc.date2014-07-30T17:47:55Z
dc.date2015-11-26T16:29:59Z
dc.date.accessioned2018-03-28T23:11:02Z
dc.date.available2018-03-28T23:11:02Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 656, n. 41699, n. 45, n. 51, 2011.
dc.identifier0014-2999
dc.identifierWOS:000288935600008
dc.identifier10.1016/j.ejphar.2011.01.025
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/68023
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/68023
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269861
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionThe crude alcoholic extracts obtained from Pterodon pubescens Benth. seeds are widely used in Brazilian folk medicine as anti-inflammatory, analgesic, anti-rheumatic tonics and depurative preparations. We previously demonstrated the antinociceptive activity on writhing capsaicin, glutamate, and hot-plate tests of two compounds isolated from P. pubescens: geranylgeraniol (C1) and 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oate methyl ester (C2). This work is a continuation of the previous study investigating the possible mechanisms of action for compounds C1 and C2, and the differences between them. The present study demonstrated that when administered intraperitoneally (i.p.): i), compounds C1 and C2 produced significant anti-allodynic activity during the acute phase of the Complete Freund's Adjuvant (CFA)-induced persistent pain model; ii) compound C1 produced significant anti-hypernociception activity in the carrageenan-induced pain model; iii) compound C2 presented a significant loss of activity after p-chlorophenylalanine methyl ester hydrochloride (PCPA) [5-HT synthesis inhibitor] treatment, suggesting that the mechanisms of action could be related to either the synthesis or release of serotonin; iv) compound C1 presented a significant loss of activity after ondansetron (5-HT(3) receptor antagonist) treatment suggesting activity upon 5-HT3 serotonin receptors; v) compound C1 presented a significant loss of activity after efaroxan (mixed I(1) imidazoline/alpha(2)-adrenoceptor antagonist) treatment suggesting the participation of this compound upon imidazoline receptors: and vi) both compounds C1 and C2 did not appear to exert their activity via 5-HT(1A), 5-HT(2A), imidazoline I(2), alpha(2)-adrenoceptor, nitric oxide, GABA(A), acetylcholine muscarinic, and nicotinic receptors when evaluated in acetic acid-induced nociception. Crown Copyright (C) 2011 Published by Elsevier B.V. All rights reserved.
dc.description656
dc.description41699
dc.description45
dc.description51
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectAnalgesia
dc.subjectPain mechanism
dc.subjectNatural product
dc.subjectPain Hypersensitivity
dc.subjectCentral Sensitization
dc.subjectNeuropathic Pain
dc.subjectReceptor
dc.subjectMice
dc.subjectPolygalaeflorus
dc.subjectExpression
dc.subjectInduction
dc.subjectCytokines
dc.subjectExtract
dc.titleGeranylgeraniol and 6 alpha,7 beta-dihydroxyvouacapan-17 beta-oate methyl ester isolated from Pterodon pubescens Benth.: Further investigation on the antinociceptive mechanisms of action
dc.typeArtículos de revistas


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