Protective Effect of Guarana (Paullinia cupana var. sorbilis) Pre-treatment on Cadmium-Induced Damages in Adult Wistar Testis

dc.creatorLeite, RP
dc.creatorWada, RS
dc.creatorMonteiro, JC
dc.creatorPredes, FS
dc.creatorDolder, H
dc.date2011
dc.dateJUN
dc.date2014-07-30T14:18:23Z
dc.date2015-11-26T16:29:28Z
dc.date2014-07-30T14:18:23Z
dc.date2015-11-26T16:29:28Z
dc.date.accessioned2018-03-28T23:10:31Z
dc.date.available2018-03-28T23:10:31Z
dc.identifierBiological Trace Element Research. Humana Press Inc, v. 141, n. 41699, n. 262, n. 274, 2011.
dc.identifier0163-4984
dc.identifierWOS:000290727800028
dc.identifier10.1007/s12011-010-8729-7
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58304
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58304
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269732
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionGuarana (Paullinia cupana) is an Amazonian plant. Its antioxidant potential was demonstrated to be due to the high polyphenol concentration. On the other hand, one of the mechanisms underlying cadmium-induced cellular damage is free radical mediated, resulting in increased oxidative processes. This study investigated P. cupana's potential to attenuate cadmium-induced damages in Wistar rat testis. Adult male Wistar rats were either pre-treated with 2 mg/g body weight (BW) of powdered P. cupana seed during 56 days and/or injected with cadmium chloride at a dose of 1.15 mg/kg BW. After cadmium exposition (48 h), testes samples were evaluated by histological and stereological analyses. Both groups exposed to cadmium presented evident morphological alterations relative to control animals. A few rodents showed massive cell death in the seminiferous epithelium and intertubular space, indicating that some animals are more sensitive to cadmium. Despite the alterations observed in both groups, pre-treatment with P. cupana was effective in attenuating morphological changes in Leydig cells, as well as reducing inflammatory response, relative to animals exclusively exposed to the metal. Animals treated only with P. cupana presented a significant increase in plasma testosterone levels and a significant increase in volumetric proportions of seminiferous tubules, which are indicative of spermatogenic stimulation.
dc.description141
dc.description41699
dc.description262
dc.description274
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherHumana Press Inc
dc.publisherTotowa
dc.publisherEUA
dc.relationBiological Trace Element Research
dc.relationBiol. Trace Elem. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectCadmium
dc.subjectRat testis
dc.subjectPaullinia cupana
dc.subjectTestosterone
dc.subjectAntioxidant Activity
dc.subjectTesticular Structure
dc.subjectLaboratory-animals
dc.subjectNitric-oxide
dc.subjectRats
dc.subjectMechanisms
dc.subjectDeath
dc.subjectZinc
dc.titleProtective Effect of Guarana (Paullinia cupana var. sorbilis) Pre-treatment on Cadmium-Induced Damages in Adult Wistar Testis
dc.typeArtículos de revistas


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