Interleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer

dc.creatorCunha, LL
dc.creatorTincani, AJ
dc.creatorda Assumpcao, LVM
dc.creatorSoares, FA
dc.creatorVassallo, J
dc.creatorWard, LS
dc.date2011
dc.date2014-07-30T14:33:58Z
dc.date2015-11-26T16:29:24Z
dc.date2014-07-30T14:33:58Z
dc.date2015-11-26T16:29:24Z
dc.date.accessioned2018-03-28T23:10:28Z
dc.date.available2018-03-28T23:10:28Z
dc.identifierClinics. Hospital Clinicas, Univ Sao Paulo, v. 66, n. 7, n. 1203, n. 1208, 2011.
dc.identifier1807-5932
dc.identifier1980-5322
dc.identifierWOS:000294436800014
dc.identifier10.1590/S1807-59322011000700014
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60444
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60444
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269720
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionOBJECTIVES: The aim of this study was to investigate the role of the interleukin-18 + 105A/C and interleukin-10-1082A/G germline polymorphisms in the development and outcome of differentiated thyroid carcinoma associated or not with concurrent thyroiditis. METHODS: We studied 346 patients with differentiated thyroid carcinomas, comprising 292 papillary carcinomas and 54 follicular carcinomas, who were followed up for 12-298 months ( mean 76.10 +/- 68.23 months) according to a standard protocol. We genotyped 200 patients and 144 control individuals for the interleukin-18 + 105A/C polymorphism, and we genotyped 183 patients and 137 controls for the interleukin-10-1082A/G polymorphism. RESULTS: Interleukin-18 polymorphisms were not associated with chronic lymphocytic thyroiditis or any clinical or pathological feature of tumor aggressiveness. However, there was an association between the presence of interleukin-10 variants and chronic lymphocytic thyroiditis. Chronic lymphocytic thyroiditis was present in 21.74% of differentiated thyroid carcinoma patients, most frequently affecting women previously diagnosed with Hashimoto's thyroiditis who had received a lower I-131 cumulative dose and did not present lymph node metastases. CONCLUSIONS: We conclude that the inheritance of a G allele at the interleukin-10 - 1082A/G polymorphism may favor a concurrent thyroid autoimmunity in differentiated thyroid carcinoma patients, and this autoimmunity may favor a better prognosis for these patients.
dc.description66
dc.description7
dc.description1203
dc.description1208
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.languageen
dc.publisherHospital Clinicas, Univ Sao Paulo
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationClinics
dc.relationClinics
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectTumor immunity
dc.subjectInterleukin-10
dc.subjectInterleukin-18
dc.subjectChronic lymphocytic thyroiditis
dc.subjectImmunogenetics
dc.subjectChronic Lymphocytic Thyroiditis
dc.subjectHashimotos-thyroiditis
dc.subjectGene Polymorphisms
dc.subjectGamma Production
dc.subjectGraves-disease
dc.subjectIl-18 Gene
dc.subjectT-cells
dc.subjectCarcinoma
dc.subjectCytokine
dc.subjectInfiltration
dc.titleInterleukin-10 but not interleukin-18 may be associated with the immune response against well-differentiated thyroid cancer
dc.typeArtículos de revistas


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