Optimized Enzymatic Synthesis of Hesperidin Fatty Acid Esters in a Two-Phase System Containing Ionic Liquid

dc.creatorde Araujo, MEMB
dc.creatorContesini, FJ
dc.creatorFranco, YEM
dc.creatorSawaya, ACHF
dc.creatorAlberto, TG
dc.creatorDalfre, N
dc.creatorCarvalho, PD
dc.date2011
dc.dateAUG
dc.date2014-08-01T18:36:58Z
dc.date2015-11-26T16:28:42Z
dc.date2014-08-01T18:36:58Z
dc.date2015-11-26T16:28:42Z
dc.date.accessioned2018-03-28T23:09:44Z
dc.date.available2018-03-28T23:09:44Z
dc.identifierMolecules. Mdpi Ag, v. 16, n. 8, n. 7171, n. 7182, 2011.
dc.identifier1420-3049
dc.identifierWOS:000294249100077
dc.identifier10.3390/molecules16087171
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/81509
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/81509
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269538
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionResponse surface methodology (RSM) based on a five-level, three-variable central composite design (CCD) was employed for modeling and optimizing the conversion yield of the enzymatic acylation of hesperidin with decanoic acid using immobilized Candida antarctica lipase B (CALB) in a two-phase system containing [bmim]BF(4). The three variables studied (molar ratio of hesperidin to decanoic acid, [bmim]BF(4)/acetone ratio and lipase concentration) significantly affected the conversion yield of acylated hesperidin derivative. Verification experiments confirmed the validity of the predicted model. The lipase showed higher conversion degree in a two-phase system using [bmim] BF4 and acetone compared to that in pure acetone. Under the optimal reaction conditions carried out in a single-step biocatalytic process when the water content was kept lower than 200 ppm, the maximum acylation yield was 53.6%.
dc.description16
dc.description8
dc.description7171
dc.description7182
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionCoordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionFAPESP [09/09224-3]
dc.languageen
dc.publisherMdpi Ag
dc.publisherBasel
dc.publisherSuíça
dc.relationMolecules
dc.relationMolecules
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectCandida antarctica
dc.subjectlipase
dc.subjecthesperidin
dc.subjectacylation
dc.subjectFlavonoids
dc.subjectLipase
dc.subjectEsterification
dc.subjectAntioxidants
dc.subjectBiocatalysis
dc.subjectParameters
dc.subjectSolubility
dc.subjectAcylation
dc.subjectChemistry
dc.subjectSolvents
dc.titleOptimized Enzymatic Synthesis of Hesperidin Fatty Acid Esters in a Two-Phase System Containing Ionic Liquid
dc.typeArtículos de revistas


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