Acute leukemias in Piaui: comparison with features observed in other regions of Brazil

dc.creatorRego, MFN
dc.creatorPinheiro, GS
dc.creatorMetze, K
dc.creatorLorand-Metze, I
dc.date2003
dc.dateMAR
dc.date2014-11-19T15:35:06Z
dc.date2015-11-26T16:28:21Z
dc.date2014-11-19T15:35:06Z
dc.date2015-11-26T16:28:21Z
dc.date.accessioned2018-03-28T23:09:20Z
dc.date.available2018-03-28T23:09:20Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 36, n. 3, n. 331, n. 337, 2003.
dc.identifier0100-879X
dc.identifierWOS:000181920300007
dc.identifier10.1590/S0100-879X2003000300007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54211
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54211
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54211
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269438
dc.descriptionDifferences in age and sex distribution as well as FAB (French-American-British classification) types have been reported for acute leukemias in several countries. We studied the demographics and response to treatment of patients with acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL) between 1989 and 2000 in Teresina, Piaui, and compared these results with reports from Brazil and other countries. Complete data concerning 345 patients (230 ALL, 115 AML) were reviewed. AML occurred predominantly in adults (77%), with a median age of 34 years, similar to that found in the southeast of Brazil but lower than the median age in the United States and Europe (52 years). FAB distribution was similar in children and adults and FAB-M2 was the most common type, as also found in Japan. The high frequency of FAB-M3 described in most Brazilian studies and for Hispanics in the United States was not observed. Overall survival for adults was 40%, similar to other studies in Brazil. A high mortality rate was observed during induction. No clinical or hematological parameter influenced survival in the Cox model. ALL presented the characteristic peak of incidence between 2-8 years. Most of the cases were CD10+pre-B ALL. In 25%, abnormal expression of myeloid antigens was observed. Only 10% of the patients were older than 30 years. Overall survival was better for children. Age and leukocyte count were independent prognostic factors. These data demonstrate that, although there are regional peculiarities, the application of standardized treatments and good supportive care make it possible to achieve results observed in other countries for the same chemotherapy protocols.
dc.description36
dc.description3
dc.description331
dc.description337
dc.languageen
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Medical And Biological Research
dc.relationBrazilian J. Med. Biol. Res.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectacute lymphoblastic leukemia
dc.subjectacute myeloid leukemia
dc.subjectepidemiology
dc.subjectAcute Myeloid-leukemia
dc.subjectAcute Promyelocytic Leukemia
dc.subjectAcute Lymphoblastic-leukemia
dc.subjectHigh-frequency
dc.subjectAdult
dc.subjectClassification
dc.subjectLatinos
dc.titleAcute leukemias in Piaui: comparison with features observed in other regions of Brazil
dc.typeArtículos de revistas


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