Antenatal ultrasound prediction of pulmonary hypoplasia in congenital diaphragmatic hernia: correlation with pathology

dc.creatorJani, JC
dc.creatorCordier, AG
dc.creatorMartinovic, J
dc.creatorPeralta, CF
dc.creatorSenat, MV
dc.creatorSegers, V
dc.creatorBenachi, A
dc.date2011
dc.dateSEP
dc.date2014-08-01T18:21:19Z
dc.date2015-11-26T16:28:15Z
dc.date2014-08-01T18:21:19Z
dc.date2015-11-26T16:28:15Z
dc.date.accessioned2018-03-28T23:09:15Z
dc.date.available2018-03-28T23:09:15Z
dc.identifierUltrasound In Obstetrics & Gynecology. Wiley-blackwell, v. 38, n. 3, n. 344, n. 349, 2011.
dc.identifier0960-7692
dc.identifierWOS:000294364800015
dc.identifier10.1002/uog.9031
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77628
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77628
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269413
dc.descriptionObjective To examine the relationship between observed to expected (o/e) lung to head circumference ratio (LHR) and lung-to-body weight ratio (LBWR) in fetuses with congenital diaphragmatic hernia (CDH). Methods All consecutive fetuses with CDH and termination of pregnancy for which a postmortem examination was available, examined at three institutions between 2000 and 2010, were included in the study. Contralateral fetal lung area was measured by two-dimensional ultrasonography using the longest axis method and the o/e-LHR was calculated based on the appropriate normal mean for gestational age (GA). Regression analysis was used to determine the significance of association between the LBWR and the o/e-LHR for left and right-sided cases, and subsequently the predicted LBWR in left-sided CDH was calculated using the regression equation. Regression analysis was used to investigate the effect on the proportional difference between the predicted and observed LBWR of GA at o/e-LHR, time gap between o/e-LHR and LBWR measurement, proportional weight of the ipsilateral compared with total lung weight, presence of associated anomalies and intrathoracic herniation of the liver. Results There were 23 fetuses with left-sided and seven fetuses with right-sided CDH. In left-sided CDH, the LBWR and the o/e-LHR correlated significantly, following the linear equation: LBWR = 0.0043 + (0.0134 x o/e-LHR) (r = 0.52, P = 0.012), but this was not the case for right-sided CDH, for which LBWR followed the equation: LBWR = 0.0107 - (0.0014 x o/e-LHR) (r = 0.08, P = 0.862), where o/e-LHR is expressed as percentage. Regression analysis showed that the proportional difference between predicted and observed LBWR in left-sided CDH was significantly and independently associated with GA at o/e-LHR measurement and proportional weight of ipsilateral vs. total lung weight. Conclusion In left-sided CDH, o/e-LHR correlates well with LBWR irrespective of the length of time between o/e-LHR and LBWR measurement, presence of associated anomalies and intrathoracic herniation of the liver. Inconsistencies between the two measurements are mainly attributable to the contribution of the ipsilateral lung to the total lung weight. In right-sided CDH, o/e-LHR does not correlate with LBWR. Copyright. (C) 2011 ISUOG. Published by John Wiley & Sons, Ltd.
dc.description38
dc.description3
dc.description344
dc.description349
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationUltrasound In Obstetrics & Gynecology
dc.relationUltrasound Obstet. Gynecol.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcongenital diaphragmatic hernia
dc.subjectlung-to-body weight ratio
dc.subjectlung to head ratio
dc.subjectprenatal diagnosis
dc.subjectTo-head Ratio
dc.subjectMagnetic-resonance
dc.subjectLung-volume
dc.subjectCircumference Ratio
dc.subjectLiver Herniation
dc.subjectFetal Lungs
dc.subjectFetuses
dc.subjectSurvival
dc.subjectArea
dc.subjectMetaanalysis
dc.titleAntenatal ultrasound prediction of pulmonary hypoplasia in congenital diaphragmatic hernia: correlation with pathology
dc.typeArtículos de revistas


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