The association of cryoglobulinaemia with sustained virological response in patients with chronic hepatitis C

dc.creatorVigani, AG
dc.creatorde Oliveira, AM
dc.creatorTozzo, R
dc.creatorPavan, MHP
dc.creatorGoncales, ES
dc.creatorFais, V
dc.creatorGoncales, NS
dc.creatorGoncales, FL
dc.date2011
dc.dateAPR
dc.date2014-08-01T18:24:07Z
dc.date2015-11-26T16:28:13Z
dc.date2014-08-01T18:24:07Z
dc.date2015-11-26T16:28:13Z
dc.date.accessioned2018-03-28T23:09:13Z
dc.date.available2018-03-28T23:09:13Z
dc.identifierJournal Of Viral Hepatitis. Wiley-blackwell, v. 18, n. 4, n. e91, n. e98, 2011.
dc.identifier1352-0504
dc.identifierWOS:000288213200011
dc.identifier10.1111/j.1365-2893.2010.01385.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/78354
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/78354
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269405
dc.descriptionPrevious reports suggest cryoglobulinemia might influence the hepatitis C virus (HCV) infection clinical course and treatment response but this association has not been thoroughly evaluated. We aimed to assess the relationship between cryoglobulinemia and sustained viral response (SVR) in patients treated for HCV infection. We included patients with HCV infection treated from January 2003 through December 2006. Biochemical analyses, detection cryoglobulinemia, and liver biopsies were performed prior to treatment. Genotype 1 or 4 infections received Peg-interferon (IFN) alpha-2a or -2b for 48 weeks; genotypes 2 or 3 received IFN alpha for 24 weeks. All patients also received ribavirin. Of 329 enrolled patients, 242 (73%) were male and the median age was 43 years. Cryoglobulinemia was detected in 196 (59.6%) patients; liver biopsy was performed in 301. Multivariate analysis showed an association of cryoglobulinemia with severe active necroinflammation (A3) (adjusted odds ratio [AOR]= 9.48; 95% confidence interval [CI]: 1.50-59.92) and rheumatoid factor (RF) level (AOR= 1.01; 95% CI: 1.00-1.02). Variables associated with advanced fibrosis were age, aspartate aminotransferase and alkaline phosphatase levels, alcohol use, and presence of diabetes. Variables independently associated with SVR were cryoglobulinemia (AOR= 2.33, 95% CI: 1.26-4.32), absence of cirrhosis (AOR= 4.5, 95% CI: 1.4-14.80), and RF level (AOR= 1.008, 95% CI: 1.001-1.014). Our findings suggest cryoglobulinemia is associated with severe necroinflammatory activity in HCV-infected patients. We also provide the first evidence for an association between cryoglobulinemia and higher SVR rates, highlighting its potential role as a prognostic factor for treatment response.
dc.description18
dc.description4
dc.descriptione91
dc.descriptione98
dc.languageen
dc.publisherWiley-blackwell
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Viral Hepatitis
dc.relationJ. Viral Hepatitis
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectChronic Hepatitis C
dc.subjectcryoglobulinemia
dc.subjectfibrosis
dc.subjectnecroinflammation
dc.subjecttreatment
dc.subjectInterferon-alpha Treatment
dc.subjectMixed Cryoglobulinemia
dc.subjectVirus-infection
dc.subjectLong-term
dc.subjectSystemic Vasculitis
dc.subjectRibavirin Treatment
dc.subjectJapanese Patients
dc.subjectTherapy
dc.subjectFibrosis
dc.subjectLiver
dc.titleThe association of cryoglobulinaemia with sustained virological response in patients with chronic hepatitis C
dc.typeArtículos de revistas


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