BCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells

dc.creatorTraina, F
dc.creatorCarvalheira, JBC
dc.creatorSaad, MJA
dc.creatorCosta, FF
dc.creatorSaad, STO
dc.date2003
dc.date10959
dc.date2014-11-17T12:29:23Z
dc.date2015-11-26T16:27:42Z
dc.date2014-11-17T12:29:23Z
dc.date2015-11-26T16:27:42Z
dc.date.accessioned2018-03-28T23:08:39Z
dc.date.available2018-03-28T23:08:39Z
dc.identifierFebs Letters. Elsevier Science Bv, v. 535, n. 41699, n. 17, n. 22, 2003.
dc.identifier0014-5793
dc.identifierWOS:000180734900005
dc.identifier10.1016/S0014-5793(02)03845-0
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55357
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55357
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55357
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269257
dc.descriptionIn the present study we used K562 cells to demonstrate that insulin receptor substrate 1 (IRS-1) is expressed and constitutively phosphorylated in BCR-ABL(+) cells. We observed association between BCR-ABL/IRS-1, IRS-1/phosphoinositide 3'-kinase (PI3-kinase), and IRS-1/Grb2 in the K562 cell line. Our findings demonstrate that imatinib treatment resulted in marked attenuation of BCR-ABL/IRS-1 association and of IRS-1-stimulated PI3-kinase activity in K562 cells. We concluded that the IRS-1 protein is involved in the signalling pathway of the BCR-ABL tyrosine kinase. (C) 2002 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.
dc.description535
dc.description41699
dc.description17
dc.description22
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationFebs Letters
dc.relationFEBS Lett.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectimatinib
dc.subjectchronic myeloid leukemia
dc.subjectBCR-ABL
dc.subjectIRS-1
dc.subjectK562 cells
dc.subjectTyrosine Kinase Inhibitor
dc.subjectInsulin-receptor Substrate-1
dc.subjectChronic Myelogenous Leukemia
dc.subjectPhosphatidylinositol 3-kinase
dc.subjectSignal-transduction
dc.subjectGrowth-factor
dc.subjectPhiladelphia-chromosome
dc.subject3t3-l1 Adipocytes
dc.subjectPositive Cells
dc.subjectProtein Irs-1
dc.titleBCR-ABL binds to IRS-1 and IRS-1 phosphorylation is inhibited by imatinib in K562 cells
dc.typeArtículos de revistas


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