Peri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction

dc.creatorSilva, JCQE
dc.creatorCoelho, OR
dc.creatorAndrade, JM
dc.creatorQuinaglia, T
dc.creatorModolo, RGP
dc.creatorAlmeida, BO
dc.creatorvan der Geest, RJ
dc.creatorJerosch-Herold, M
dc.creatorCoelho, OR
dc.creatorSposito, AC
dc.date2014
dc.dateJUN
dc.date2014-07-30T14:31:11Z
dc.date2015-11-26T16:26:49Z
dc.date2014-07-30T14:31:11Z
dc.date2015-11-26T16:26:49Z
dc.date.accessioned2018-03-28T23:07:41Z
dc.date.available2018-03-28T23:07:41Z
dc.identifierInflammation. Springer/plenum Publishers, v. 37, n. 3, n. 678, n. 685, 2014.
dc.identifier0360-3997
dc.identifier1573-2576
dc.identifierWOS:000336397900005
dc.identifier10.1007/s10753-013-9784-y
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59299
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59299
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1269006
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionEnhanced systemic inflammatory activity (SIA) during myocardial infarction (MI) and the extent of the peri-infarct zone characterized by cardiac magnetic resonance imaging (CMRi) are both associated with increased risk of life-threatening arrhythmias and sudden cardiac death. The present study investigated the existence of association between these two phenomena in 98 patients (55 +/- 10 years) with ST segment elevation MI. Plasma levels of C-reactive protein (CRP), interleukin-2 (IL-2), and tumor necrosis factor (TNF) were measured on admission (D1) and on the fifth day post-MI (D5). CMRi was performed 2 weeks after MI to quantify peri-infarct zone (PIZ). Between D1 and D5, the increase in CRP (6.0 vs. 5.6 times; p = 0.02), IL-2 (3.6 vs. 3.4 times; p = 0.04) and tumor necrosis factor type alpha (TNF-alpha; 4.6 vs. 3.9 times; p = 0.001) were higher in patients with PIZ above the median than in the counterparts. PIZ was correlated with CRP-D5 (r = 0.69), delta-CRP (r = 0.7), IL-2-D5 (r = 0.5), delta-IL-2 (r = 0.6), TNF-alpha (r = 0.5), delta-TNF-alpha (r = 0.4; p = 0.0001). Enhanced activation of SIA during the acute phase of MI is directly related with generation of PIZ.
dc.description37
dc.description3
dc.description678
dc.description685
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionAHA Postdoctoral Fellowship Award [AHA 11POST5550053]
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionCNPq [300313/2007-1]
dc.descriptionAHA Postdoctoral Fellowship Award [AHA 11POST5550053]
dc.languageen
dc.publisherSpringer/plenum Publishers
dc.publisherNew York
dc.publisherEUA
dc.relationInflammation
dc.relationInflammation
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectmyocardial infarction
dc.subjectinflammation
dc.subjectmagnetic resonance imaging
dc.subjectperi-infarct zone
dc.subjectMortality
dc.subjectHeterogeneity
dc.subjectApoptosis
dc.subjectCytokines
dc.titlePeri-Infarct Zone Characterized by Cardiac Magnetic Resonance Imaging is Directly Associated with the Inflammatory Activity During Acute Phase Myocardial Infarction
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución