Angiotensin-converting enzyme and apolipoproteins genes polymorphism in coronary artery disease

dc.creatorMansur, AP
dc.creatorAnnicchino-Bizzacchi, J
dc.creatorFavarato, D
dc.creatorAvakian, SD
dc.creatorCesar, LAM
dc.creatorRamires, JAF
dc.date2000
dc.dateMAY
dc.date2014-12-02T16:26:09Z
dc.date2015-11-26T16:26:08Z
dc.date2014-12-02T16:26:09Z
dc.date2015-11-26T16:26:08Z
dc.date.accessioned2018-03-28T23:06:54Z
dc.date.available2018-03-28T23:06:54Z
dc.identifierClinical Cardiology. Clinical Cardiology Publ Co, v. 23, n. 5, n. 335, n. 340, 2000.
dc.identifier0160-9289
dc.identifierWOS:000086771200005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/77436
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/77436
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/77436
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268805
dc.descriptionBackground: Association between angiotensin-converting enzyme (ACE) as well as apolipoprotein (apo) AI, B, and E polymorphisms and dyslipidemia and coronary artery disease (CAD) is controversial. Hypothesis: This study assessed the distribution of ACE insertion/deletion, apo AI A/G mutation, apo B signal peptide insertion/deletion, apo B XbaI restriction fragment length, and apo E polymorphisms in 388 nondiabetic patients. Methods: The study population included 112 patients with stable CAD, 139 patients with acute myocardial infarction (AMI), and 137 age-matched control subjects. Results: Univariate analysis showed higher prevalence of XbaI X+/X+ genotype in patients with CAD (p = 0.02). Angiotensin-converting enzyme and apo polymorphisms were not associated with Lipid levels or severity of CAD. When all genotypes known to be related to CAD, such as ACE DD, apo Al GG, apo B del/del, and XbaI X+X+, and Ecl allele of apo E, were pooled, again no significant differences among groups were seen. Multivariate regression analysis disclosed traditional risk factors and elevated levels of apo B for men and reduced levels of apo AI for women as independent variables for CAD. Conclusions: In addition to traditional coronary risk factors, apo B and AI could be considered predictors of CAD. No association between either form of CAD and polymorphisms was noted.
dc.description23
dc.description5
dc.description335
dc.description340
dc.languageen
dc.publisherClinical Cardiology Publ Co
dc.publisherMahwah
dc.publisherEUA
dc.relationClinical Cardiology
dc.relationClin. Cardiol.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjectcoronary artery disease
dc.subjectangiotensin-converting enzyme
dc.subjectapolipoprotein AI
dc.subjectapolipoprotein B
dc.subjectapolipoprotein E
dc.subjectgene polymorphism
dc.subjectgenetics
dc.subjectIschemic-heart-disease
dc.subjectA-i Promoter
dc.subjectMyocardial-infarction
dc.subjectLinkage Disequilibrium
dc.subjectDeletion Polymorphism
dc.subjectDna Polymorphisms
dc.subject-78 Position
dc.subjectRisk Factor
dc.subjectE Alleles
dc.subjectAtherosclerosis
dc.titleAngiotensin-converting enzyme and apolipoproteins genes polymorphism in coronary artery disease
dc.typeArtículos de revistas


Este ítem pertenece a la siguiente institución