An ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice

dc.creatorBuzukov, AA
dc.creatorIlasova, VB
dc.creatorTabak, M
dc.creatorMeirelles, NC
dc.creatorDegterev, IA
dc.date1996
dc.date45717
dc.date2014-12-16T11:36:49Z
dc.date2015-11-26T16:25:39Z
dc.date2014-12-16T11:36:49Z
dc.date2015-11-26T16:25:39Z
dc.date.accessioned2018-03-28T23:06:24Z
dc.date.available2018-03-28T23:06:24Z
dc.identifierChemico-biological Interactions. Elsevier Sci Ireland Ltd, v. 100, n. 2, n. 113, n. 124, 1996.
dc.identifier0009-2797
dc.identifierWOS:A1996UK96100002
dc.identifier10.1016/0009-2797(96)03694-0
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54384
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54384
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54384
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268678
dc.descriptionThis work extends a previous study on the mechanism of hepatic denitration of two nitroheterocyclic drugs (NHCD), quinifuryl and nitracrine, in which the release of nitric oxide (NO) from these compounds can be accompanied by the formation of a NO-heme iron complex, Pretreating mice with three inducers of cytochrome P-450 (phenobarbital, clophen A50 and butylated hydroxytoluene (BHT)) increased the yield of the nitrosyl complex which correlated with a rise in the cytochrome P-450 content of mouse liver microsomes. In contrast, treating the animals with beta-naphthoflavone decreased the complex yield while still increasing P-450 content, Treating the animals with any of the above inducers significantly increased the rate of NHCD metabolism in mouse liver microsomes. Based on these results, a possible mechanism for hepatic NHCD denitration is discussed.
dc.description100
dc.description2
dc.description113
dc.description124
dc.languageen
dc.publisherElsevier Sci Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationChemico-biological Interactions
dc.relationChem.-Biol. Interact.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectnitroheterocyclic drugs
dc.subjecthepatic denitration
dc.subjectmicrosomal consumption
dc.subjectnitrosyl complex
dc.subjectESR
dc.subjectNitric-oxide
dc.subjectMechanism
dc.subjectTransformation
dc.subjectPeroxynitrite
dc.subjectReduction
dc.subjectOxygen
dc.titleAn ESR and spectrophotometric study of the denitration of nitroheterocyclic drugs by liver homogenates and their metabolic consumption by liver microsomes from cytochrome P-450-induced mice
dc.typeArtículos de revistas


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