Abnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy

dc.creatorCoan, AC
dc.creatorKobayashi, E
dc.creatorLopes-Cendes, I
dc.creatorLi, LM
dc.creatorCendes, F
dc.date2004
dc.dateJUN
dc.date2014-11-16T22:15:55Z
dc.date2015-11-26T16:25:35Z
dc.date2014-11-16T22:15:55Z
dc.date2015-11-26T16:25:35Z
dc.date.accessioned2018-03-28T23:06:21Z
dc.date.available2018-03-28T23:06:21Z
dc.identifierBrazilian Journal Of Medical And Biological Research. Assoc Bras Divulg Cientifica, v. 37, n. 6, n. 827, n. 832, 2004.
dc.identifier0100-879X
dc.identifierWOS:000221864900007
dc.identifier10.1590/S0100-879X2004000600007
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/53990
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/53990
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/53990
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268665
dc.descriptionMesial temporal lobe epilepsy (MTLE) is associated with hippocampal atrophy and hippocampal signal abnormalities. In our series of familial MTLE (FMTLE), we found a high proportion of hippocampal abnormalities. To quantify signal abnormalities in patients with FMTLE we studied 152 individuals (46 of them asymptomatic) with FMTLE. We used NIH-Image(R) for volumetry and signal quantification in coronal T1 inversion recovery and T2 for all cross-sections of the hippocampus. Values diverging by 2 or more SD from the control mean were considered abnormal. T2 hippocampal signal abnormalities were found in 52% of all individuals: 54% of affected subjects and 48% of asymptomatic subjects. T1 hippocampal signal changes were found in 34% of all individuals: 42.5% of affected subjects and 15% of asymptomatic subjects. Analysis of the hippocampal head (first three slices) revealed T2 abnormalities in 73% of all individuals (74% of affected subjects and 72% of asymptomatic subjects) and T1 abnormalities in 5 9% (67% of affected subjects and 41% of asymptomatic subjects). Affected individuals had smaller volumes than controls (P < 0.0001). There was no difference in hippocampal volumes between asymptomatic subjects and controls, although 39% of asymptomatic patients had hippocampal atrophy. Patients with an abnormal hippocampal signal (133 individuals) had smaller ipsilateral volume, but no linear correlation could be determined. Hippocampal signal abnormalities in FMTLE were more frequently found in the hippocampal head in both affected and asymptomatic family members, including those with normal volumes. These results indicate that subtle abnormalities leading to an abnormal hippocampal signal in FMTLE are not necessarily related to seizures and may be determined by genetic factors.
dc.description37
dc.description6
dc.description827
dc.description832
dc.languageen
dc.publisherAssoc Bras Divulg Cientifica
dc.publisherSao Paulo
dc.publisherBrasil
dc.relationBrazilian Journal Of Medical And Biological Research
dc.relationBrazilian J. Med. Biol. Res.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjecthippocampal signal abnormalities
dc.subjectfamilial mesial temporal lobe epilepsy
dc.subjecthippocampal volumetry
dc.subjectmagnetic resonance imaging
dc.subjectSclerosis
dc.subjectNeuropathology
dc.subjectPathology
dc.subjectAtrophy
dc.titleAbnormalities of hippocampal signal intensity in patients with familial mesial temporal lobe epilepsy
dc.typeArtículos de revistas


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