Poly(vinyl alcohol) Films for Topical Delivery of S-Nitrosoglutathione: Effect of Freezing-Thawing on the Diffusion Properties

dc.creatorSimoes, MMDG
dc.creatorde Oliveira, MG
dc.date2010
dc.dateMAY
dc.date2014-11-16T22:10:15Z
dc.date2015-11-26T16:25:23Z
dc.date2014-11-16T22:10:15Z
dc.date2015-11-26T16:25:23Z
dc.date.accessioned2018-03-28T23:06:09Z
dc.date.available2018-03-28T23:06:09Z
dc.identifierJournal Of Biomedical Materials Research Part B-applied Biomaterials. Wiley-liss, v. 93B, n. 2, n. 416, n. 424, 2010.
dc.identifier1552-4973
dc.identifierWOS:000276715800016
dc.identifier10.1002/jbm.b.31598
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/70658
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/70658
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/70658
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268620
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionPoly(vinyl alcohol) (PVA) is a biocompatible polymer already used in several pharmaceutical products The purpose of this work was to investigate the influence of freezing-thawing cycles (F/T) on the in vitro diffusion and skin vasodilator properties of S-nitrosoglutathione (GSNO)-releasing PVA films Films subjected to 1-, 3-, and 5-F/T showed an increase in crystallinity, which is associated with an increase in the radius of gyration of macropores from 155 to 180 nm Diffusion coefficients ID) of GSNO decreased from 57 x 10(-7) to 2 0 x 10(-7) cm(2) s(-1) in 1 and 3 F/T films, respectively, and were inversely correlated with the increase in crystallinity, whereas 5-F/T films showed an anomalous increase in D (5 0 x 10 7 cm(2) s(-1)) Topical release of GSNO from PVA films on the skin of healthy volunteers led to local vasodilation measured by laser Doppler flowmetry A higher increase in local blood flow was observed for 5-F/T films reaching maximum tissue perfusion at 45 min with return toward basal level after 45 min, whereas 1-F/T films led to a lower increase in blood flow up to 98 min These results show that F/T treatment can be used to modulate the diffusion properties and the topical vasodilator profile of GSNO-containing PVA films, what might allow the use of these materials as dermal wound dressings or for promoting local vasodilation in ischemic tissues (C) 2010 Wiley Periodicals, Inc J Biomed Mater Res Part B Appl Biomater 93B 416 424, 2010
dc.description93B
dc.description2
dc.description416
dc.description424
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.descriptionScitech Medical
dc.descriptionFINEP
dc.descriptionConselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)
dc.languageen
dc.publisherWiley-liss
dc.publisherHoboken
dc.publisherEUA
dc.relationJournal Of Biomedical Materials Research Part B-applied Biomaterials
dc.relationJ. Biomed. Mater. Res. Part B
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectpoly(vinyl alcohol)
dc.subjectfreezing-thawing
dc.subjectdiffusion
dc.subjectS-nitrosoglutathione
dc.subjectnitric oxide
dc.subjectvasodilation
dc.subjectNitric-oxide Donors
dc.subjectDrug-delivery
dc.subjectEndothelial Dysfunction
dc.subjectDiabetic Foot
dc.subjectContact-lens
dc.subjectHydrogels
dc.subjectRelease
dc.subjectSystems
dc.subjectMicrocirculation
dc.subjectMicrospheres
dc.titlePoly(vinyl alcohol) Films for Topical Delivery of S-Nitrosoglutathione: Effect of Freezing-Thawing on the Diffusion Properties
dc.typeArtículos de revistas


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