Pharmacological activities investigation of crude extracts and fractions from Qualea grandiflora Mart

dc.creatorGaspi, FOG
dc.creatorFoglio, MA
dc.creatorCarvalho, JE
dc.creatorMoreno, RA
dc.date2006
dc.dateAUG 11
dc.date2014-11-16T10:18:10Z
dc.date2015-11-26T16:21:58Z
dc.date2014-11-16T10:18:10Z
dc.date2015-11-26T16:21:58Z
dc.date.accessioned2018-03-28T23:03:44Z
dc.date.available2018-03-28T23:03:44Z
dc.identifierJournal Of Ethnopharmacology. Elsevier Ireland Ltd, v. 107, n. 1, n. 19, n. 24, 2006.
dc.identifier0378-8741
dc.identifierWOS:000239676000004
dc.identifier10.1016/j.jep.2006.01.023
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/59401
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/59401
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/59401
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1268024
dc.descriptionThis study investigates pharmacological activities of crude hydroalcoholic extract and fractions of Qualea grandiflora Mart. leaves employing different experimental models using mice. The treatment with crude hydroalcoholic extract (EH) in a dose of 500 mg/kg, i.p. caused: signs of central nervous system depressant action in the Hippocratic screening test, confirmed by the potentiation of sodium pentobarbital sleeping time. Increasing in the latency time of hot plate assay that indicate an analgesic effect; significantly delaying of the onset of clonic PTZ convulsions, increasing in the time for death, suppressing of the tonic PTZ convulsion, and decreasing of severity and number of convulsions. The median lethal dose of EH was 1.321 mg/kg. The convulsions induced by PTZ, ethyl ether fraction (300 mg/kg, i.p.) was more active in increasing the latency time for first convulsion, moreover, the hexane fraction, at the same dose, was more active in increasing the time for death and/or avoiding the death. Both did not cause disturbance in motor coordination at the dose of 500 mg/kg, assessed by rotarod test. These results suggest that the crude extract of leaves of Qualea grandiflora Mart. has a central nervous system depressant action, an analgesic effect and behave as a potential anticonvulsant. (c) 2006 Elsevier Ireland Ltd. All rights reserved.
dc.description107
dc.description1
dc.description19
dc.description24
dc.languageen
dc.publisherElsevier Ireland Ltd
dc.publisherClare
dc.publisherIrlanda
dc.relationJournal Of Ethnopharmacology
dc.relationJ. Ethnopharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectQualea grandiflora
dc.subjectvochysiaceae
dc.subjectanticonvulsants
dc.subjectmedicinal plant
dc.subjectAntiepileptic Drugs
dc.subjectModels
dc.titlePharmacological activities investigation of crude extracts and fractions from Qualea grandiflora Mart
dc.typeArtículos de revistas


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