Acute administration of nicotine impairs the hypotensive responses to bradykinin in rats

dc.creatorPaganelli, MO
dc.creatorTanus-Santos, JE
dc.creatorToledo, JCY
dc.creatordo Prado, JF
dc.creatorCalegari, V
dc.creatorMoreno, H
dc.date2001
dc.dateFEB 16
dc.date2014-11-16T09:41:28Z
dc.date2015-11-26T16:21:38Z
dc.date2014-11-16T09:41:28Z
dc.date2015-11-26T16:21:38Z
dc.date.accessioned2018-03-28T23:03:35Z
dc.date.available2018-03-28T23:03:35Z
dc.identifierEuropean Journal Of Pharmacology. Elsevier Science Bv, v. 413, n. 41700, n. 241, n. 246, 2001.
dc.identifier0014-2999
dc.identifierWOS:000167270200014
dc.identifier10.1016/S0014-2999(01)00744-0
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/54187
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/54187
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/54187
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267987
dc.descriptionNicotine may contribute to smoking-induced endothelial dysfunction because of its ability to impair endothelium-dependent vasodilatation. We investigated whether the acute administration of nicotine changes the hypotensive responses to bradykinin in rats. The effects of pre-treatment with losartan or enalapril on the nicotine-induced changes in the responses to bradykinin were also evaluated. In study 1, anesthetized rats were cannulated via carotid artery for the measurement of mean arterial pressure. Dose-response curves to bradykinin (0.1, 0.4, 1.6, 6.4, 25 and 100 mug/kg) were generated before and 10 min after the injection of nicotine (200 mug/kg, i.v.) or saline. The individual dose-response curves were fitted to a four-parameter logistic equation using the ALLFIT program, which provided an estimate of the maximal response (E-max) and of the dose of bradykinin producing the half-maximal response (ED50). In study 2, rats were pre-treated orally with losartan (10 mg/kg/day) or enalapril maleate (25 mg/kg/day) for 2 weeks. Control rats received tap water alone. After pre-treatment, the rats were anesthetized and used as described in study 1. Nicotine decreased the E-max (from 73.0 +/- 7.5 to 65.7 +/- 3.3 mm Hg; P < 0.05) but did not affect the ED50. In study 2, losartan or enalapril did not affect nicotine-induced decrease in responses to bradykinin; E-max decreased in both groups (from 68.7 +/- 6.3 to 62.8 +/- 4.2 mm Hg, and from 53.8 +/- 13.0 to 43.1 +/- 7.1 mm Hg, respectively; P < 0.05) without significantly changing the ED50. These results suggest that nicotine impairs the endothelium-dependent hypotensive responses to bradykinin. This effect is not influenced by inhibition of the angiotensin-converting enzyme or by blockade of the angiotensin AT(1) receptors. (C) 2001 Elsevier Science B.V. All rights reserved.
dc.description413
dc.description41700
dc.description241
dc.description246
dc.languageen
dc.publisherElsevier Science Bv
dc.publisherAmsterdam
dc.publisherHolanda
dc.relationEuropean Journal Of Pharmacology
dc.relationEur. J. Pharmacol.
dc.rightsfechado
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectblood pressure
dc.subjectbradykinin
dc.subjectendothelial dysfunction
dc.subjectenalapril
dc.subjectlosartan
dc.subjectnicotine
dc.subjectConverting Enzyme-inhibition
dc.subjectCigarette-smoke Extract
dc.subjectEndothelial Dysfunction
dc.subjectNitric-oxide
dc.subjectCardiovascular-disease
dc.subjectHypertensive Rats
dc.subjectAngiotensin
dc.subjectCells
dc.subjectCaptopril
dc.subjectDilatation
dc.titleAcute administration of nicotine impairs the hypotensive responses to bradykinin in rats
dc.typeArtículos de revistas


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