Prostatic diseases in the senescence: structural and proliferative features

dc.creatorHetzl, AC
dc.creatorFavaro, WJ
dc.creatorBillis, A
dc.creatorFerreira, U
dc.creatorCagnon, VHA
dc.date2010
dc.dateJUN
dc.date2014-11-16T06:32:20Z
dc.date2015-11-26T16:20:31Z
dc.date2014-11-16T06:32:20Z
dc.date2015-11-26T16:20:31Z
dc.date.accessioned2018-03-28T23:02:56Z
dc.date.available2018-03-28T23:02:56Z
dc.identifierAging Male. Informa Healthcare, v. 13, n. 2, n. 124, n. 132, 2010.
dc.identifier1368-5538
dc.identifierWOS:000277224000009
dc.identifier10.3109/13685531003586991
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/58285
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/58285
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/58285
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267827
dc.descriptionSenescence is one of the main aetiological factors which are responsible for natural androgen ablation in men and occurrence of prostatic diseases. However, it is unclear how the prostatic lesions are signallised in the prostate. Thus, the aim of this study is to characterise the structural, the ultrastructural and the proliferative aspects of the peripheral prostatic zone in the elderly men with and without diagnoses of prostatic lesions and with potential precursors of prostate cancer. Sixty samples of prostatic tissue, from 60 to 90-year-old patients with and without lesions obtained from autopsied or prostatectomised patients were divided into four groups (15 samples per group): standard group (no lesions), benign prostatic hyper-plasia group, high-grade prostatic intra-epithelial neoplasia group and prostatic carcinoma group. The samples were submitted to morphometrical, structural and ultrastructural analyses in addition to cellular apoptosis and proliferative analyses. The results showed morphological damages in the stroma and cellular organelles involved in the secretory process of the prostate. Moreover, the prostatic lesions in elderly men demonstrated disturbance in the proliferation/apoptosis rate, indicating a prevalence of the proliferative process. Finally, the imbalance in prostatic stroma-epithelium interaction was a harmful feature in the elderly men as a result of structural changes, which are crucial factors for the development and progression of carcinogenesis.</.
dc.description13
dc.description2
dc.description124
dc.description132
dc.languageen
dc.publisherInforma Healthcare
dc.publisherLondon
dc.publisherInglaterra
dc.relationAging Male
dc.relationAging Male
dc.rightsfechado
dc.rightshttp://informahealthcare.com/userimages/ContentEditor/1255620309227/Copyright_And_Permissions.pdf
dc.sourceWeb of Science
dc.subjectProstate cancer
dc.subjectprostatic intra-epithelial neoplasia
dc.subjectbenign prostatic hyperplasia
dc.subjectsenescence
dc.subjectCancer Progression
dc.subjectCell-proliferation
dc.subjectAndrogen Receptor
dc.subjectVentral Prostate
dc.subjectEpithelial-cells
dc.subjectReactive Stroma
dc.subjectBasal-cells
dc.subjectIn-vivo
dc.subjectCarcinogenesis
dc.subjectTissue
dc.titleProstatic diseases in the senescence: structural and proliferative features
dc.typeArtículos de revistas


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