Differential proliferation of fibroblasts cultured from hereditary gingival fibromatosis and normal gingiva

dc.creatorColetta, RD
dc.creatorAlmeida, OP
dc.creatorGraner, E
dc.creatorPage, RC
dc.creatorBozzo, L
dc.date1998
dc.dateNOV
dc.date2014-12-02T16:25:45Z
dc.date2015-11-26T16:19:44Z
dc.date2014-12-02T16:25:45Z
dc.date2015-11-26T16:19:44Z
dc.date.accessioned2018-03-28T23:02:33Z
dc.date.available2018-03-28T23:02:33Z
dc.identifierJournal Of Periodontal Research. Munksgaard Int Publ Ltd, v. 33, n. 8, n. 469, n. 475, 1998.
dc.identifier0022-3484
dc.identifierWOS:000077751400005
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/61809
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/61809
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/61809
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267733
dc.descriptionHereditary gingival fibromatosis (HGF) is an oral condition characterized by the enlargement of the gingiva of both the maxilla and mandible. To study the cell proliferation index of fibroblasts from HGF and normal gingiva (NG), cell cultures from 4 members of the same family with HGF and from 4 healthy patients were established. Our results obtained from 6 different cell proliferation assays clearly showed that the cell proliferation rate was significantly higher in fibroblasts from HGF than from normal gingiva. HGF and control fibroblasts in subconfluent culture densities were typically spindle, but in saturation density HGF cells were shorter than control cells. These data suggest that the higher proliferative index of HGF fibroblasts possibly has a role in the pathogenesis of gingival outgrowth in HGF patients.
dc.description33
dc.description8
dc.description469
dc.description475
dc.languageen
dc.publisherMunksgaard Int Publ Ltd
dc.publisherCopenhagen
dc.publisherDinamarca
dc.relationJournal Of Periodontal Research
dc.relationJ. Periodont. Res.
dc.rightsfechado
dc.sourceWeb of Science
dc.subjecthereditary gingival fibromatosis
dc.subjectgingiva
dc.subjectfibroblast
dc.subjectproliferation index
dc.subjectNucleolar Organizer Regions
dc.subjectPhenytoin 5,5-diphenylhydantoin
dc.subjectGrowth-factors
dc.subjectHyperplasia
dc.subjectCollagen
dc.subjectTissue
dc.subjectNifedipine
dc.titleDifferential proliferation of fibroblasts cultured from hereditary gingival fibromatosis and normal gingiva
dc.typeArtículos de revistas


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