Interleukin-6 stimulates tubular regeneration in rats with glycerol-induced acute renal failure

dc.creatorHomsi, E
dc.creatorRibeiro-Alves, MA
dc.creatorde Faria, JBL
dc.creatorDias, EPO
dc.date2002
dc.dateSEP
dc.date2014-11-16T02:44:52Z
dc.date2015-11-26T16:18:56Z
dc.date2014-11-16T02:44:52Z
dc.date2015-11-26T16:18:56Z
dc.date.accessioned2018-03-28T23:02:07Z
dc.date.available2018-03-28T23:02:07Z
dc.identifierNephron. Karger, v. 92, n. 1, n. 192, n. 199, 2002.
dc.identifier0028-2766
dc.identifierWOS:000177788500025
dc.identifier10.1159/000064478
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/60447
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/60447
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/60447
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267627
dc.descriptionInterleukin-6 stimulates tubular regeneration in rats with glycerol-induced acute renal failure. Background. Interleukin 6 (IL-6) is a pleiotropic cytokine released after endotoxemia, trauma and organ injury. IL-6 may act in cellular proliferation activating transduction signals and Ras/Map cascade or the HGF/c-met axis. We tested the effect of IL-6 in the regeneration of tubular epithelia after acute tubular necrosis (ATN) in rats. Methods: Rats with glycerol-induced acute renal failure (Gly-ARF) were treated with IL-6 200 mug/kg/day. Functional, histological and immunohistochemical tests were done 24 and 72 h after Gly-ARF to localise mitotic cells (BrdU). The renal expression of c-met (Western-Blot) and circulating levels of HGF (ELISA) were also determined. Results: Rats with Gly-ARF had reduced creatinine clearance that was not influenced by IL-6. The histological appearance of ATN was also unaffected by IL-6. The IL-6 treated rats showed a significant increase in tubular cell proliferation in cortex and medulla, as well as in the expression of c-met protein in the renal cortex, compared to untreated Gly-ARF rats. The plasma HGF concentration was equally elevated in treated and untreated Gly-ARF rats. Discussion: IL-6 stimulates tubular regeneration after Gly-ARF and increases the expression of c-met in the renal cortex. Gly-ARF rats have high circulating levels of HGF that is targeted to act in the injured kidneys by the IL-6 overexpressed renal c-met. Copyright (C) 2002 S. Karger AG, Basel.
dc.description92
dc.description1
dc.description192
dc.description199
dc.languageen
dc.publisherKarger
dc.publisherBasel
dc.publisherSuíça
dc.relationNephron
dc.relationNephron
dc.rightsfechado
dc.rightshttp://www.karger.com/Services/RightsPermissions
dc.sourceWeb of Science
dc.subjectacute renal failure
dc.subjecttubular regeneration
dc.subjectHGF/c-met axis
dc.subjectinterleukin-6
dc.subjectHepatocyte Growth-factor
dc.subjectAccelerates Recovery
dc.subjectReperfusion Injury
dc.subjectEpithelial-cells
dc.subjectMessenger-rna
dc.subjectC-met
dc.subjectCytokines
dc.subjectExpression
dc.subjectIl-6
dc.subjectProliferation
dc.titleInterleukin-6 stimulates tubular regeneration in rats with glycerol-induced acute renal failure
dc.typeArtículos de revistas


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