Blood-brain barrier breakdown following gliotoxic drug injection in the brainstern of Wistar rats

dc.creatorBondan, EF
dc.creatorLallo, MA
dc.creatorDagli, MLZ
dc.creatorPereira, LAVD
dc.creatorGraca, DL
dc.date2002
dc.dateSEP
dc.date2014-11-15T19:38:46Z
dc.date2015-11-26T16:13:41Z
dc.date2014-11-15T19:38:46Z
dc.date2015-11-26T16:13:41Z
dc.date.accessioned2018-03-28T23:01:12Z
dc.date.available2018-03-28T23:01:12Z
dc.identifierArquivos De Neuro-psiquiatria. Assoc Arquivos De Neuro- Psiquiatria, v. 60, n. 3A, n. 582, n. 589, 2002.
dc.identifier0004-282X
dc.identifierWOS:000177767200013
dc.identifier10.1590/S0004-282X2002000400013
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55789
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55789
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55789
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267395
dc.descriptionEthidium bromide (EB) causes local astrocytic disappearance, with glia limitans disruption and supposed blood-brain barrier (BBB) breakdown The aim of this study was to investigate the BBB integrity after the injection of 0.1% EB (group E) or 0.9% saline solution (group Q into cisterna pontis of Wistar rats. Brainstem fragments were collected from 24 hours to 31 days post-injection for ultrastructural study and GFAP immuno-histochemical staining. Some animals received colloidal carbon ink by intravenous route at the same periods. In rats from group C, there was no sign of astrocyte loss and no leakage of ink from blood vessels in the injection site. In group E, astrocyte disappearance began at 48 hours and some areas were still devoid of astrocytic processes 31 days after. Leakage of carbon particles was seen from 48 hours to 7 days in the EB-induced lesions. Tight junctions did not show any detectable ultrastructural change due to the lack of perivascular astrocytes.
dc.description60
dc.description3A
dc.description582
dc.description589
dc.languagept
dc.publisherAssoc Arquivos De Neuro- Psiquiatria
dc.publisherSao Paulo Sp
dc.publisherBrasil
dc.relationArquivos De Neuro-psiquiatria
dc.relationArq. Neuro-Psiquiatr.
dc.rightsaberto
dc.sourceWeb of Science
dc.subjectastrocytes
dc.subjectblood-brain-barrier
dc.subjectcentral nervous system
dc.subjectethidium bromide
dc.subjectgliotoxic
dc.subjectrats
dc.subjectEthidium-bromide
dc.subjectRemyelination
dc.titleBlood-brain barrier breakdown following gliotoxic drug injection in the brainstern of Wistar rats
dc.typeArtículos de revistas


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