Chromatographic separation of bupivacaine enantiomers by HPLC: Parameters estimation of equilibrium and mass transfer under linear conditions

dc.creatorDa Silva, IJ
dc.creatorDe Veredas, I
dc.creatorCarpes, MJS
dc.creatorSantana, CS
dc.date2005
dc.dateMAR
dc.date2014-11-15T18:55:58Z
dc.date2015-11-26T16:13:01Z
dc.date2014-11-15T18:55:58Z
dc.date2015-11-26T16:13:01Z
dc.date.accessioned2018-03-28T23:00:58Z
dc.date.available2018-03-28T23:00:58Z
dc.identifierAdsorption-journal Of The International Adsorption Society. Springer, v. 11, n. 2, n. 123, n. 129, 2005.
dc.identifier0929-5607
dc.identifierWOS:000234015400003
dc.identifier10.1007/s10450-005-4903-1
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/55850
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/55850
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/55850
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267344
dc.descriptionBupivacaine is an amide type local anesthetic widely used in surgery and obstetrics because of its sustained peripheral and central nerve blockade. R-(+)-bupivacaine is more toxic to the central nervous and the cardiovascular systems than S-(-)-bupivacaine. To obtain S-(-)- bupivacaine with high degree of purity using a continuous simulated moving bed (SMB) unity, equilibrium and mass transfer parameters under dilute conditions were obtained by pulse experiments using 0,0'-bis[4-terc-butyl-benzoyl]- N, N'- diallyl-L-tartar diamide immobilized in silica (Kromasil(R) CHI-TBB). The linear equilibrium constants were found to be 2.12 and 2.91 for R-(+)and S-(-)- bupivacaine, respectively. Axial dispersion coefficients were found to be practically the same for both enantiomers. A fast kinetic of mass transfer was observed. The internal resistance to the mass transfer controls all the mass transfer process in this chiral column and the pore diffusion coefficients were of the order 10(-7) cm(2)/s. The equilibrium and mass transfer parameters will be employed in future simulation and design of operating conditions of SMB unity.
dc.description11
dc.description2
dc.description123
dc.description129
dc.languageen
dc.publisherSpringer
dc.publisherDordrecht
dc.publisherHolanda
dc.relationAdsorption-journal Of The International Adsorption Society
dc.relationAdsorpt.-J. Int. Adsorpt. Soc.
dc.rightsfechado
dc.rightshttp://www.springer.com/open+access/authors+rights?SGWID=0-176704-12-683201-0
dc.sourceWeb of Science
dc.subjectchiral separations
dc.subjectpreparative liquid chromatography
dc.subjectmass transfer
dc.subjectequilibrium
dc.subjectbupivacaine
dc.subjectSimulated Moving-bed
dc.subjectChiral Stationary Phases
dc.subjectSmb Chromatography
dc.subjectPerformance
dc.subjectResolution
dc.subjectNadolol
dc.subjectDrug
dc.titleChromatographic separation of bupivacaine enantiomers by HPLC: Parameters estimation of equilibrium and mass transfer under linear conditions
dc.typeArtículos de revistas


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