D,L-cis-2,3-pyrrolidine dicarboxylate alters [H-3]-L-glutamate binding and induces convulsions in mice

dc.creatorSinhorin, VDG
dc.creatorCarpes, MJS
dc.creatorRoehrs, C
dc.creatorZimmer, MF
dc.creatorSauzem, PD
dc.creatorRubin, MA
dc.creatorCorreia, CRD
dc.creatorMello, CF
dc.date2003
dc.dateSEP
dc.date2014-11-15T18:06:52Z
dc.date2015-11-26T16:12:54Z
dc.date2014-11-15T18:06:52Z
dc.date2015-11-26T16:12:54Z
dc.date.accessioned2018-03-28T23:00:52Z
dc.date.available2018-03-28T23:00:52Z
dc.identifierPharmacology Biochemistry And Behavior. Pergamon-elsevier Science Ltd, v. 76, n. 2, n. 295, n. 299, 2003.
dc.identifier0091-3057
dc.identifierWOS:000186550200010
dc.identifier10.1016/j.pbb.2003.08.012
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/79154
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/79154
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/79154
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267317
dc.descriptionThis study investigated whether D,L-cis-2,3-Pyrrolidine dicarboxylate (D,L-cis-2,3-PDC), a new glutamate analogue, alters glutamate binding to cerebral plasma membranes and whether N-methyl-D-aspartate (NMDA) receptors are involved in the convulsant effect of this compound. D,L-cis-2,3-PDC reduced sodium-independent [H-3]-L-glutamate binding to lysed membrane preparations from adult rat cortex and had no effect on sodium-dependent glutamate binding. Intracerebroventricular administration Of D,L-cis-2,3-PDC (7.5-25 nmol/5 mul) induced generalized tonic-clonic convulsions in mice in a dose-dependent manner. The coadministration of MK-801 (7 nmol/2.5 mul), with D,L-cis-2,3-PDC (16.5 nmol/2.5 mul), fully protected the animals against D,L-cis-2,3-PDC-induced convulsions, while the coadministration of DNQX (10 nmol/2.5 mul) increased the latency to convulsions but did not alter the percentage of animals that had convulsions. These results suggest that D,L-cis-2,3-PDC-induced effects are mediated predominantly by NMDA receptors. (C) 2003 Elsevier Inc. All rights reserved.
dc.description76
dc.description2
dc.description295
dc.description299
dc.languageen
dc.publisherPergamon-elsevier Science Ltd
dc.publisherOxford
dc.publisherInglaterra
dc.relationPharmacology Biochemistry And Behavior
dc.relationPharmacol. Biochem. Behav.
dc.rightsaberto
dc.rightshttp://www.elsevier.com/about/open-access/open-access-policies/article-posting-policy
dc.sourceWeb of Science
dc.subjectbinding
dc.subjectconvulsion
dc.subjectglutamate
dc.subjectMK-801
dc.subjectDNQX
dc.subjectintracerebroventricular administration
dc.subjectMetabotropic Glutamate Receptors
dc.subjectRat Spinal-cord
dc.subjectNeuronal Death
dc.subjectNmda Receptor
dc.subjectDomoic Acid
dc.subjectAgonist
dc.subjectPotent
dc.subjectAntagonists
dc.subjectExcitotoxicity
dc.subjectAnalogs
dc.titleD,L-cis-2,3-pyrrolidine dicarboxylate alters [H-3]-L-glutamate binding and induces convulsions in mice
dc.typeArtículos de revistas


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