Oral ulcers in HIV-positive Peruvian patients: an immunohistochemical and in situ hybridization study

dc.creatorDelgado, WA
dc.creatorAlmeida, OP
dc.creatorVargas, PA
dc.creatorLeon, JE
dc.date2009
dc.dateJAN
dc.date2014-11-15T17:06:41Z
dc.date2015-11-26T16:12:27Z
dc.date2014-11-15T17:06:41Z
dc.date2015-11-26T16:12:27Z
dc.date.accessioned2018-03-28T23:00:40Z
dc.date.available2018-03-28T23:00:40Z
dc.identifierJournal Of Oral Pathology & Medicine. Wiley-blackwell Publishing, Inc, v. 38, n. 1, n. 120, n. 125, 2009.
dc.identifier0904-2512
dc.identifierWOS:000261979900018
dc.identifier10.1111/j.1600-0714.2008.00714.x
dc.identifierhttp://www.repositorio.unicamp.br/jspui/handle/REPOSIP/69691
dc.identifierhttp://www.repositorio.unicamp.br/handle/REPOSIP/69691
dc.identifierhttp://repositorio.unicamp.br/jspui/handle/REPOSIP/69691
dc.identifier.urihttp://repositorioslatinoamericanos.uchile.cl/handle/2250/1267268
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionThis study describes the histopathological, immunohistochemical (IHC) and in situ hybridization (ISH) data of 25 cases of oral ulcers in HIV-positive patients, with clinical and microscopical features similar to ulcers not otherwise specified (NOS)/necrotizing ulcerative stomatitis (NUS). Sex, age and clinical history were obtained from the clinical records. Histological analysis for H&E, Gomori-Grocott and Ziehl-Neelsen stains, IHC analysis to detect infectious agents and to characterize inflammatory cellular infiltrate, and ISH for cytomegalovirus (CMV) and EBER1/2 were performed. Twenty-one patients were men and four were women (mean age of 34.6 years). The tongue was preferentially affected. Microscopically, the lesions showed extensive necrosis, leukocytoclasia, vasculitis with luminal fibrin clots and an intense inflammatory cellular infiltrate predominated by CD68(+) atypical large cells, normal-sized and crescent-shaped nuclei macrophages, interspersed by CD8(+) T lymphocytes. Mast cells were also observed in all samples studied. CD4(+) T lymphocytes, CD20(+) B lymphocytes and VS38c(+) plasma cells were practically absent. CMV and EBER1/2 were identified in scarce cells of 3 and 16 of 25 cases respectively. These results show that CD68(+) macrophages, followed by CD8(+) T lymphocytes, were the predominant inflammatory cells, indicating they are relevant to the pathogenesis of the ulcers, possibly reflecting an abnormal immune response in the oral mucosa. The clinicopathological and immunoprofile features of the present cases are similar to NOS ulcers/NUS in HIV-positive patients.
dc.description38
dc.description1
dc.description120
dc.description125
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.descriptionFundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)
dc.languageen
dc.publisherWiley-blackwell Publishing, Inc
dc.publisherMalden
dc.publisherEUA
dc.relationJournal Of Oral Pathology & Medicine
dc.relationJ. Oral Pathol. Med.
dc.rightsfechado
dc.rightshttp://olabout.wiley.com/WileyCDA/Section/id-406071.html
dc.sourceWeb of Science
dc.subjectcytomegalovirus
dc.subjectEpstein-Barr virus
dc.subjectmacrophages
dc.subjectnecrotizing ulcerative stomatitis
dc.subjectnot otherwise specified ulcers
dc.subjectT lymphocytes
dc.subjectRecurrent Aphthous Ulcers
dc.subjectInfected Patients
dc.subjectStomatitis
dc.subjectLesions
dc.subjectAids
dc.subjectPeriodontitis
dc.subjectAssociation
dc.subjectDisease
dc.subjectCells
dc.titleOral ulcers in HIV-positive Peruvian patients: an immunohistochemical and in situ hybridization study
dc.typeArtículos de revistas


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